Cited 21 times in
Effects of LNG-IUS on nerve growth factor and its receptors expression in patients with adenomyosis.
DC Field | Value | Language |
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dc.contributor.author | 이경은 | - |
dc.contributor.author | 이병석 | - |
dc.contributor.author | 임경진 | - |
dc.contributor.author | 전영은 | - |
dc.contributor.author | 조시현 | - |
dc.contributor.author | 최영식 | - |
dc.contributor.author | 김혜연 | - |
dc.contributor.author | 서석교 | - |
dc.contributor.author | 양효인 | - |
dc.date.accessioned | 2015-04-23T17:35:08Z | - |
dc.date.available | 2015-04-23T17:35:08Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0897-7194 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/102749 | - |
dc.description.abstract | The levonorgestrel-releasing intrauterine system (LNG-IUS) is effective in the treatment of dysmenorrhea associated with adenomyosis. However, the mechanism of pain relief of LNG-IUS in patients with adenomyosis is unclear. We aimed to investigate the effects of LNG-IUS on the expression of nerve growth factor (NGF) and its receptors, NGFR p75 and TrkA in patients with adenomyosis. Endometrial and myometrial tissues were prepared from 17 LNG-IUS-treated patients and 15 hormonally untreated patients who had undergone hysterectomies for adenomyosis. Immunohistochemistry with antibodies against NGF, NGFR p75, and TrkA, was performed. The expression of NGF, NGFR p75, and TrkA in endometrium and myometrium of LNG-IUS-treated patients was significantly decreased compared to those of hormonally untreated patients. Our findings may indicate that the suppression of NGF and its receptors by LNG-IUS is another possible mechanism of relieving pain in patients with adenomyosis. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 452~460 | - |
dc.relation.isPartOf | GROWTH FACTORS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Dysmenorrhea/drug therapy | - |
dc.subject.MESH | Endometriosis/drug therapy | - |
dc.subject.MESH | Endometriosis/metabolism* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fluorescent Antibody Technique | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Levonorgestrel/administration & dosage* | - |
dc.subject.MESH | Levonorgestrel/therapeutic use | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Nerve Growth Factor/genetics | - |
dc.subject.MESH | Nerve Growth Factor/metabolism* | - |
dc.subject.MESH | Receptors, Nerve Growth Factor/genetics | - |
dc.subject.MESH | Receptors, Nerve Growth Factor/metabolism* | - |
dc.title | Effects of LNG-IUS on nerve growth factor and its receptors expression in patients with adenomyosis. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Obstetrics & Gynecology (산부인과학) | - |
dc.contributor.googleauthor | Young Sik Choi | - |
dc.contributor.googleauthor | SiHyun Cho | - |
dc.contributor.googleauthor | Kyung Jin Lim | - |
dc.contributor.googleauthor | Young Eun JEON | - |
dc.contributor.googleauthor | Hyo In Yang | - |
dc.contributor.googleauthor | Kyung Eun Lee | - |
dc.contributor.googleauthor | Kamdar Heena | - |
dc.contributor.googleauthor | Seok Kyo Seo | - |
dc.contributor.googleauthor | Hye Yeon Kim | - |
dc.contributor.googleauthor | Byung Seok Lee Read More: http://informahealthcare.com/doi/abs/10.3109/08977194.2010.511619 | - |
dc.identifier.doi | 10.3109/08977194.2010.511619 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02795 | - |
dc.contributor.localId | A03356 | - |
dc.contributor.localId | A03533 | - |
dc.contributor.localId | A03846 | - |
dc.contributor.localId | A04114 | - |
dc.contributor.localId | A01174 | - |
dc.contributor.localId | A01888 | - |
dc.contributor.localId | A02329 | - |
dc.contributor.localId | A02650 | - |
dc.relation.journalcode | J03145 | - |
dc.identifier.eissn | 1029-2292 | - |
dc.identifier.pmid | 20854189 | - |
dc.identifier.url | http://informahealthcare.com/doi/abs/10.3109/08977194.2010.511619 | - |
dc.subject.keyword | Nerve growth factor | - |
dc.subject.keyword | NGF receptor p75 | - |
dc.subject.keyword | NGF-specific tyrosine kinase receptor-A (TrkA) | - |
dc.subject.keyword | immunohistochemistry | - |
dc.subject.keyword | adenomyosis | - |
dc.contributor.alternativeName | Lee, Kyung Eun | - |
dc.contributor.alternativeName | Lee, Byung Seok | - |
dc.contributor.alternativeName | Lim, Kyung Jin | - |
dc.contributor.alternativeName | Jeon, Young Eun | - |
dc.contributor.alternativeName | Cho, Si Hyun | - |
dc.contributor.alternativeName | Choi, Young Sik | - |
dc.contributor.alternativeName | Kim, Hye Yeon | - |
dc.contributor.alternativeName | Seo, Seok Kyo | - |
dc.contributor.alternativeName | Yang, Hyo In | - |
dc.contributor.affiliatedAuthor | Lee, Byung Seok | - |
dc.contributor.affiliatedAuthor | Lim, Kyung Jin | - |
dc.contributor.affiliatedAuthor | Jeon, Young Eun | - |
dc.contributor.affiliatedAuthor | Cho, Si Hyun | - |
dc.contributor.affiliatedAuthor | Choi, Young Sik | - |
dc.contributor.affiliatedAuthor | Kim, Hye Yeon | - |
dc.contributor.affiliatedAuthor | Seo, Seok Kyo | - |
dc.contributor.affiliatedAuthor | Yang, Hyo In | - |
dc.contributor.affiliatedAuthor | Lee, Kyung Eun | - |
dc.citation.volume | 28 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 452 | - |
dc.citation.endPage | 460 | - |
dc.identifier.bibliographicCitation | GROWTH FACTORS, Vol.28(6) : 452-460, 2010 | - |
dc.identifier.rimsid | 56937 | - |
dc.type.rims | ART | - |
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