406 302

Cited 48 times in

Thiolated dextran-coated gold nanorods for photothermal ablation of inflammatory macrophages

DC Field Value Language
dc.contributor.author서진석-
dc.contributor.author양재문-
dc.contributor.author허용민-
dc.date.accessioned2015-04-23T17:32:39Z-
dc.date.available2015-04-23T17:32:39Z-
dc.date.issued2010-
dc.identifier.issn0743-7463-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/102670-
dc.description.abstractThiolated dextran-coated gold nanorods (DEX-GNRs) were synthesized for targeted delivery to inflammatory macrophages and their photothermal ablation under near-infrared (NIR) light irradiation. Successful synthesis of DEX-GNRs was achieved using thiolated dextran, generated by applying mercaptopropionic acid to transform a hydroxyl group of dextran into a thiol group which has strong binding affinity with surfaces of GNRs. We confirmed both the existence of a thiol group in the functionalized dextran using Ellman's reagent in a thiol group assay and the characteristic band of DEX-GNRs using FT-IR spectrum. Furthermore, a cellular uptake study revealed that dextran showed a superior ability to bind the GNRs surface against macrophages compared to those of PEGylated GNRs with various molecular weights of polyethyleneglycol (PEG). Consequently, an in vitro photothermal irradiation experiment using NIR light indicated that DEX-GNRs exhibited a significant cell-killing efficacy, even with a lower concentration of Au and a low-power light source-
dc.description.statementOfResponsibilityopen-
dc.format.extent17520~17527-
dc.relation.isPartOfLANGMUIR-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAblation Techniques/methods*-
dc.subject.MESHAnimals-
dc.subject.MESHBiological Transport-
dc.subject.MESHCell Line-
dc.subject.MESHCell Proliferation/drug effects-
dc.subject.MESHCell Survival/drug effects-
dc.subject.MESHDextrans/chemistry*-
dc.subject.MESHDextrans/metabolism-
dc.subject.MESHDextrans/pharmacology*-
dc.subject.MESHDextrans/toxicity-
dc.subject.MESHGold/chemistry*-
dc.subject.MESHInflammation/pathology-
dc.subject.MESHInflammation/surgery-
dc.subject.MESHInfrared Rays-
dc.subject.MESHMacrophages/drug effects*-
dc.subject.MESHMacrophages/pathology-
dc.subject.MESHMacrophages/radiation effects-
dc.subject.MESHMolecular Weight-
dc.subject.MESHNanotubes/chemistry*-
dc.subject.MESHPolyethylene Glycols/chemistry-
dc.subject.MESHTemperature-
dc.titleThiolated dextran-coated gold nanorods for photothermal ablation of inflammatory macrophages-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학)-
dc.contributor.googleauthorRayun Choi-
dc.contributor.googleauthorJaemoon Yang-
dc.contributor.googleauthorJihye Choi-
dc.contributor.googleauthorEun-Kyung Lim-
dc.contributor.googleauthorEunjung Kim-
dc.contributor.googleauthorJin-Suck Suh-
dc.contributor.googleauthorYong-Min Huh-
dc.contributor.googleauthorSeungjoo Haam-
dc.identifier.doi10.1021/la1029728-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02315-
dc.contributor.localIdA01916-
dc.contributor.localIdA04359-
dc.relation.journalcodeJ02155-
dc.identifier.eissn1520-5827-
dc.identifier.pmid20929199-
dc.contributor.alternativeNameSuh, Jin Suck-
dc.contributor.alternativeNameYang, Jae Moon-
dc.contributor.alternativeNameHuh, Yong Min-
dc.contributor.affiliatedAuthorYang, Jae Moon-
dc.contributor.affiliatedAuthorSuh, Jin Suck-
dc.contributor.affiliatedAuthorHuh, Yong Min-
dc.citation.volume26-
dc.citation.number22-
dc.citation.startPage17520-
dc.citation.endPage17527-
dc.identifier.bibliographicCitationLANGMUIR, Vol.26(22) : 17520-17527, 2010-
dc.identifier.rimsid56420-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.