Cited 5 times in
Synthesis of aminated polysorbate 80 for polyplex-mediated gene transfection
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 서진석 | - |
dc.contributor.author | 양재문 | - |
dc.contributor.author | 허용민 | - |
dc.date.accessioned | 2015-04-23T17:32:37Z | - |
dc.date.available | 2015-04-23T17:32:37Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 8756-7938 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/102669 | - |
dc.description.abstract | To develop novel gene delivery carriers, aminated polysorbate 80 (P80-NH(2)) was synthesized with strong positively charged properties through the introduction of three amine groups. The resulting P80-NH(2) and DNA polyplex exhibited superb condensation abilities due to the high densities of positively charged amines groups. Size and surface charge of polyplex were shown to be well suited for cellular internalization. In addition, the P80-NH(2) /DNA polyplex demonstrated acceptable transfection efficiency in HeLa cells and was nontoxic relative to the conventional 25-kDa polyethyleneimine system. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1528~1533 | - |
dc.relation.isPartOf | BIOTECHNOLOGY PROGRESS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Amination | - |
dc.subject.MESH | Antineoplastic Agents/chemical synthesis* | - |
dc.subject.MESH | Antineoplastic Agents/chemistry | - |
dc.subject.MESH | Antineoplastic Agents/pharmacology | - |
dc.subject.MESH | Apoptosis/drug effects | - |
dc.subject.MESH | Cell Survival/drug effects | - |
dc.subject.MESH | DNA/chemistry* | - |
dc.subject.MESH | Drug Carriers/chemical synthesis* | - |
dc.subject.MESH | Drug Carriers/chemistry | - |
dc.subject.MESH | Drug Carriers/pharmacology | - |
dc.subject.MESH | Drug Screening Assays, Antitumor | - |
dc.subject.MESH | Gene Transfer Techniques* | - |
dc.subject.MESH | Green Fluorescent Proteins/chemistry | - |
dc.subject.MESH | HeLa Cells | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Materials Testing | - |
dc.subject.MESH | Molecular Structure | - |
dc.subject.MESH | Particle Size | - |
dc.subject.MESH | Plasmids/chemistry | - |
dc.subject.MESH | Polysorbates/chemical synthesis* | - |
dc.subject.MESH | Polysorbates/chemistry | - |
dc.subject.MESH | Polysorbates/pharmacology | - |
dc.subject.MESH | Structure-Activity Relationship | - |
dc.subject.MESH | Surface Properties | - |
dc.subject.MESH | Transfection | - |
dc.title | Synthesis of aminated polysorbate 80 for polyplex-mediated gene transfection | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학) | - |
dc.contributor.googleauthor | Eun-Kyung Lim | - |
dc.contributor.googleauthor | Jaemoon Yang | - |
dc.contributor.googleauthor | Jin-Suck Suh | - |
dc.contributor.googleauthor | Yong-Min Huh | - |
dc.contributor.googleauthor | Seungjoo Haam | - |
dc.identifier.doi | 10.1002/btpr.475 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02315 | - |
dc.contributor.localId | A01916 | - |
dc.contributor.localId | A04359 | - |
dc.relation.journalcode | J03120 | - |
dc.identifier.eissn | 1520-6033 | - |
dc.identifier.pmid | 20662085 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1002/btpr.475/abstract | - |
dc.contributor.alternativeName | Suh, Jin Suck | - |
dc.contributor.alternativeName | Yang, Jae Moon | - |
dc.contributor.alternativeName | Huh, Yong Min | - |
dc.contributor.affiliatedAuthor | Yang, Jae Moon | - |
dc.contributor.affiliatedAuthor | Suh, Jin Suck | - |
dc.contributor.affiliatedAuthor | Huh, Yong Min | - |
dc.citation.volume | 26 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1528 | - |
dc.citation.endPage | 1533 | - |
dc.identifier.bibliographicCitation | BIOTECHNOLOGY PROGRESS, Vol.26(6) : 1528-1533, 2010 | - |
dc.identifier.rimsid | 56419 | - |
dc.type.rims | ART | - |
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