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Chronic effect of ferulic acid from Pseudosasa japonica leaves on enhancing exercise activity in mice

Authors
 Yanghee You  ;  Kyungmi Kim  ;  Ho-Geun Yoon  ;  Kwang-Won Lee  ;  Jeongmin Lee  ;  Jiyeon Chun  ;  Dong-Hoon Shin  ;  Jeongjin Park  ;  Woojin Jun 
Citation
 PHYTOTHERAPY RESEARCH, Vol.24(10) : 1508-1513, 2010 
Journal Title
 PHYTOTHERAPY RESEARCH 
ISSN
 0951-418X 
Issue Date
2010
MeSH
Animals ; Antioxidants/pharmacology ; Coumaric Acids/pharmacology* ; Free Radical Scavengers/pharmacology ; Lipid Peroxidation ; Male ; Mice ; Mice, Inbred ICR ; Motor Activity/drug effects* ; Physical Endurance/drug effects* ; Plant Leaves/chemistry ; Poaceae/chemistry* ; Swimming
Abstract
Ferulic acid derived from Pseudosasa japonica leaves, which possessed antioxidative potentials with DPPH- (54%) and ABTs- (65%) radical scavenging activities, and lipid-peroxidation inhibitory activity (71%), was orally administered to mice for 12 days in order to investigate its effects on exercise endurance capacity and alterations of antioxidant defense systems. Exhaustive swimming time was increased in the ferulic acid-supplemented group compared with the control group on days 6 and 12 (1.7- and 1.8-fold, respectively). When the mice were exhaustively exercised for 2 consecutive days, a high decrease (53%) was shown in the control group, but no change was found in the ferulic acid-treated group. The administration of ferulic acid significantly protected the depletion of enzymatic- and non enzymatic-antioxidants due to exhaustive exercise. Also, lipid-peroxidation levels decreased in the ferulic acid-treated group compared with the non exercised- and control-groups. These results suggest that ferulic acid from Pseudosasa japonica leaves has a chronic effect on endurance exercise capacity, which is attributed to its ability to ameliorate oxidative stress by improving antioxidant potentials.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/ptr.3152/abstract
DOI
10.1002/ptr.3152
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
Yonsei Authors
Yoon, Ho Geun(윤호근) ORCID logo https://orcid.org/0000-0003-2718-3372
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/102631
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