Purpose: To evaluate the pain experienced by patients and perceived by doctors during interventional breast procedures Materials and Methods: From March 2009 to August 2009, a total of 697 interventional breast procedures were performed in 674 patients. All patients and 13 treating doctors were asked to fill out a questionnaire of pain scale using VAS (Visual Analogue Scale) after their procedure. Level of pain reported by patients and doctors was compared. And the significance of variables such as patients’ age, procedure time, local anesthetics and lesion characteristics was evaluated. Results: There were significant differences in the level of pain between the experienced pain by patients and the perceived pain by doctors (mean experienced pain score 3.15±2.01 vs mean perceived pain score 3.80±1.64, p<0.01). There was no significant difference between different procedure types (p = 0.11). The level of pain was reported significantly higher with malignant lesion (benign 2.93±1.91 vs malignancy 3.79±2.19, p<0.01). There was no significant relationship between pain levels and patients’age, procedure time or local anesthetics. Conclusion: The mean pain score was 3.15/10 (moderate pain) during interventional breast procedure. This study has shown that the mean perceived pain score was higher than the mean experienced pain score and the patients with malignant lesion experienced more pain.