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Association of endothelial nitric oxide synthase polymorphisms and haplotypes with ischemic stroke in Korean individuals with or without diabetes mellitus

Authors
 OK JOON KIM  ;  UN -KYUNG KIM  ;  SEUN G HUN OH  ;  YONG WOO K CHO  ;  KYUNG IM OH  ;  DO YEUN OH  ;  YOUNG SEOK PARK  ;  NAM KEUN KIM 
Citation
 MOLECULAR MEDICINE REPORTS, Vol.3(3) : 509-513, 2010 
Journal Title
MOLECULAR MEDICINE REPORTS
ISSN
 1791-2997 
Issue Date
2010
Abstract
Polymorphisms of the endothelial nitric oxide synthase (eNOS) gene have been implicated in various diseases associated with cardiovascular risk factors, but little is known regarding the risks of ischemic stroke (IS) in patients with diabetes mellitus (DM). In this study, we evaluated the genotypes and haplotypes of three eNOS polymorphisms (-786T>C, 4a4b and 894G>T) in a Korean population of 223 IS patients and 206 controls classified into four groups: healthy subjects, type 2 DM patients without IS, IS patients without type 2 DM and IS patients with type 2 DM. The genotype frequency of 4a4b in the controls with type 2 DM differed significantly from that in the controls without DM (4b4b vs. 4a4b; OR=2.769; 95% CI 1.233-6.220) and the frequency of the -786C-4a-894G haplotype was higher in the controls with DM compared to the controls without DM (P=0.040). Additionally, the -786C-4b-894G haplotype was more common in the cases with DM than in the controls without type 2 DM (P=0.034). Our findings suggest that the eNOS 4a allele-associated genotype and haplotype is a risk factor for type 2 DM, and that the -786C-4b-894G haplotype is a risk factor for IS with DM.
Files in This Item:
T201004017.pdf Download
DOI
10.3892/mmr_00000289
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Park, Young Seok(박영석)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/102572
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