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Distribution of lymphoid neoplasms in the Republic of Korea: analysis of 5318 cases according to the World Health Organization classification.

 Sun Och Yoon  ;  Cheolwon Suh  ;  Dae Ho Lee  ;  Hyun-Sook Chi  ;  Chan Jeoung Park  ;  Seong-Soo Jang  ;  Hai-Rim Shin  ;  Bong-Hee Park  ;  Jooryung Huh 
 American Journal of Hematology, Vol.85(10) : 760-764, 2010 
Journal Title
 American Journal of Hematology 
Issue Date
Adolescent ; Adult ; Aged ; Female ; Hodgkin Disease/epidemiology ; Hodgkin Disease/pathology ; Humans ; Immunophenotyping ; Incidence ; Lymphoma/classification ; Lymphoma/epidemiology* ; Lymphoma/pathology ; Lymphoma, B-Cell/epidemiology ; Lymphoma, B-Cell/pathology ; Lymphoma, B-Cell, Marginal Zone/epidemiology ; Lymphoma, B-Cell, Marginal Zone/pathology ; Lymphoma, T-Cell/epidemiology ; Lymphoma, T-Cell/pathology ; Male ; Middle Aged ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/epidemiology ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology ; Republic of Korea/epidemiology ; Retrospective Studies ; World Health Organization ; Young Adult
Compared with the West, the overall incidence of lymphoid neoplasms is lower, and the subtype distribution is distinct in Asia. To comprehensively investigate the subtype distribution with the age and sex factors, and temporal changes of subtype proportions, we re-assessed all patients with lymphoid neoplasms diagnosed at a large oncology service in the Republic of Korea from 1989 to 2008 using the World Health Organization classifications. Of the total 5,318 patients, 66.9% had mature B-cell neoplasms, 12.5% had mature T/natural killer (NK)-cell neoplasms, 16.4% had precursor lymphoblastic leukemia/lymphoma (ALL/LBL), and 4.1% had Hodgkin's lymphoma. The most common subtypes were diffuse large B-cell lymphoma (30.5%), plasma cell myeloma (14.0%), extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue type (MALT lymphoma; 12.4%), B-cell ALL/LBL (11.3%), Hodgkin's lymphoma (4.1%), peripheral T-cell lymphoma unspecified (4.0%), T-cell ALL/LBL (3.9%), and extranodal NK/T-cell lymphoma of nasal type (3.9%). Most subtypes showed male predominance, with an average M/F ratio of 1.3. Most mature lymphoid neoplasms were diseases of adults (mean age, 53.5 yr), whereas ALL/LBLs were of young individuals (mean age, 20.3 yr). When the relative proportion of subtypes were compared between two decades (1989-1998 vs. 1999-2008), especially MALT lymphoma has increased in proportion, whereas T/NK-cell neoplasms and ALL/LBL have slightly decreased. In summary, the lymphoid neoplasms of Koreans shared some epidemiologic features similar to those of other countries, whereas some subtypes showed distinct features. Although the increase in incidence of lymphoid neoplasms is relatively modest in Korea, recent increase of MALT lymphoma and decrease of T/NK-cell neoplasms and ALL/LBL are interesting findings.
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1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Yoon, Sun Och(윤선옥) ORCID logo https://orcid.org/0000-0002-5115-1402
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