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양극성장애와 Catechol O-Methyltransferase 및 Monoamine Oxidase A 유전자 다형성의 연관성

Other Titles
 Associatin Between Catechol O-Methyltransferase Gene, Monoamine Ocidase A Gene and Bipolar Disorder 
Authors
 김승준  ;  조현상  ;  김세주  ;  전덕인  ;  이은  ;  석정호  ;  송동호 
Citation
 Journal of Korean Society for Depressive and Bipolar Disorders (우울ㆍ조울병), Vol.8(1) : 24-30, 2010 
Journal Title
 Journal of Korean Society for Depressive and Bipolar Disorders (우울ㆍ조울병) 
ISSN
 1738-0960 
Issue Date
2010
Abstract
involved in metabolizing the monoamine, are associated with the onset of bipolar disorder or the clinical variables such as suicide attempt during illness, age of onset and family history. This study investigated the genotype or allele frequency of COMT and MAOA genes in bipolar disorder patients and compared the results to those of healthy controls. Method:We collected the blood of 184 bipolar patients and 216 healthy controls. COMT Val158Met and MAOA EcoRV/C1460T were genotyped. T-test, analysis of variance, chi-square test and Fisher’s exact test were used. Results:There was no significant association between COMT Val158Met and MAOA EcoRV/C1460T and onset of bipolar disorder. In the bipolar patients group, there was no significant association between COMT Val158Met and MAOA EcoRV/C1460T and clinical variables such as suicidal attempt during illness, family history and age of onset. Conclusion:The present findings indicate that there is no association between COMT Val158Met and MAOA EcoRV/C1460T and onset of bipolar disorder or clinical variables such as suicidal attempt during illness, age of onset and family history.
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Joo(김세주) ORCID logo https://orcid.org/0000-0002-5438-8210
Kim, Seung Jun(김승준)
Seok, Jeong Ho(석정호) ORCID logo https://orcid.org/0000-0002-9402-7591
Song, Dong Ho(송동호) ORCID logo https://orcid.org/0000-0002-9647-3130
Lee, Eun(이은) ORCID logo https://orcid.org/0000-0002-7462-0144
Cho, Hyun Sang(조현상) ORCID logo https://orcid.org/0000-0003-1019-9941
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/102550
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