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Relationship between white blood cell count and nonalcoholic fatty liver disease.

Authors
 Yong-Jae Lee  ;  Hye-Ree Lee  ;  Jae-Yong Shim  ;  Byung-Soo Moon  ;  Jung-Hyun Lee  ;  Jong-Koo Kim 
Citation
 DIGESTIVE AND LIVER DISEASE, Vol.42(12) : 888-894, 2010 
Journal Title
 DIGESTIVE AND LIVER DISEASE 
ISSN
 1590-8658 
Issue Date
2010
MeSH
Adult ; Aged ; Cross-Sectional Studies ; Fatty Liver*/diagnostic imaging ; Fatty Liver*/immunology ; Female ; Humans ; Leukocyte Count* ; Male ; Middle Aged ; Non-alcoholic Fatty Liver Disease ; Ultrasonography ; Young Adult
Keywords
White blood cell ; Inflammation ; Insulin resistance ; Nonalcoholic fatty liver disease
Abstract
BACKGROUND: Higher levels of white blood cell (WBC) count are known to be associated with metabolic syndrome and insulin resistance. Nonalcoholic fatty liver disease (NAFLD) is also considered a hepatic manifestation of insulin resistance. AIMS: The present study aimed to determine the relation between WBC count and the presence of NAFLD based on abdominal sonographic findings. METHODS: A cross-sectional study with 3681 healthy subjects (2066 men, 1615 women) undergoing medical check-up was conducted. The odds ratios (ORs) and 95% confidence intervals (CIs) for NAFLD were calculated using multivariate logistic regression analyses across WBC quartiles. RESULTS: A graded independent relationship between higher levels of WBC count and the prevalence risk of NAFLD was observed. After adjusting for age, smoking status, regular exercise, body mass index (BMI), blood pressure, fasting plasma glucose, triglyceride, and HDL-cholesterol, the ORs (95% CIs) for NAFLD according to WBC quartiles were 1.00, 1.48 (1.10-1.98), 1.59 (1.18-2.14), and 1.84 (1.35-2.51) for men and 1.00, 1.15 (0.67-1.96), 1.88 (1.13-3.11), and 2.74 (1.68-4.46) for women. CONCLUSIONS: WBC count was found to be independently associated with the presence of NAFLD regardless of classical cardiovascular risk factors and other components of metabolic syndrome.
Full Text
http://www.sciencedirect.com/science/article/pii/S1590865810001362
DOI
10.1016/j.dld.2010.04.005
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jong Koo(김종구)
Moon, Byung Soo(문병수)
Shim, Jae Yong(심재용) ORCID logo https://orcid.org/0000-0002-9561-9230
Lee, Yong Jae(이용제) ORCID logo https://orcid.org/0000-0002-6697-476X
Lee, Hye Ree(이혜리)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/102526
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