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Relationship of hepatic steatosis and alanine aminotransferase with coronary calcification

Authors
 Dong-Hyuk Jung  ;  Yong-Jae Lee  ;  Hong-Yup Ahn  ;  Jae-Yong Shim  ;  Hye-Ree Lee 
Citation
 CLINICAL CHEMISTRY AND LABORATORY MEDICINE, Vol.48(12) : 1829-1834, 2010 
Journal Title
 CLINICAL CHEMISTRY AND LABORATORY MEDICINE 
ISSN
 1434-6621 
Issue Date
2010
MeSH
Adult ; Aged ; Alanine Transaminase/blood* ; Calcinosis ; Coronary Artery Disease/diagnosis* ; Coronary Artery Disease/etiology ; Cross-Sectional Studies ; Fatty Liver/complications* ; Female ; Humans ; Male ; Middle Aged
Keywords
alanine aminotransferase ; coronary calcification ; hepatic steatosis
Abstract
BACKGROUND: It has been observed that hepatic steatosis is related to an increased risk of cardiovascular disease (CVD). Alanine aminotransferase (ALT), an indicator of the severity of hepatic steatosis is also associated with CVD. This study focused on the relationship between hepatic steatosis and ALT with coronary calcification. METHODS: We performed a cross-sectional study to examine the association between hepatic steatosis and serum ALT with coronary calcification in 1218 subjects (772 men, 446 women; ages 30-75 years). We evaluated hepatic steatosis and ALT as categorical variables, and constructed four groups (reference group; only with hepatic steatosis; only with ALT >30 U/L; with both hepatic steatosis and ALT >30 U/L), which did not overlap. Multi-detected row computed tomography (MDCT) was used to measure coronary calcium score. RESULTS: The adjusted ORs (95% CIs) for coronary calcification in the four groups were 1.00 (reference), 1.24 (0.68-2.26), 1.82 (0.78-4.23), and 2.12 (1.08-4.20) after adjusting for confounding variables. In addition, an increase in serum ALT activity of 10 U/L was associated with an increased risk of coronary atherosclerosis. CONCLUSIONS: In summary, patients with both hepatic steatosis and increases in ALT are associated with coronary calcification as a marker of coronary atherosclerosis determined by MDCT. This finding suggested that subjects with both hepatic steatosis and increased ALT should be considered for further evaluation of coronary atherosclerosis.
Full Text
http://www.degruyter.com/doi/10.1515/CCLM.2010.349
DOI
10.1515/CCLM.2010.349
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Shim, Jae Yong(심재용) ORCID logo https://orcid.org/0000-0002-9561-9230
Lee, Yong Jae(이용제) ORCID logo https://orcid.org/0000-0002-6697-476X
Lee, Hye Ree(이혜리)
Jung, Dong Hyuk(정동혁) ORCID logo https://orcid.org/0000-0002-3411-0676
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/102522
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