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Honokiol inhibits the progression of collagen-induced arthritis by reducing levels of pro-inflammatory cytokines and matrix metalloproteinases and blocking oxidative tissue damage.

 Ki Rim Kim  ;  Kwang-Kyun Park  ;  Kyung-Soo Chun  ;  Won-Yoon Chung 
 Journal of Pharmacological Sciences, Vol.114(1) : 69-78, 2010 
Journal Title
 Journal of Pharmacological Sciences 
Issue Date
Animals ; Arthritis, Experimental/metabolism ; Arthritis, Experimental/pathology ; Arthritis, Experimental/prevention & control* ; Biphenyl Compounds/pharmacology ; Biphenyl Compounds/therapeutic use* ; Cattle ; Cytokines/antagonists & inhibitors* ; Cytokines/biosynthesis ; Disease Progression* ; Inflammation/metabolism ; Inflammation/pathology ; Inflammation/prevention & control ; Inflammation Mediators/antagonists & inhibitors ; Inflammation Mediators/metabolism ; Inflammation Mediators/therapeutic use* ; Lignans/pharmacology ; Lignans/therapeutic use* ; Male ; Matrix Metalloproteinase Inhibitors* ; Matrix Metalloproteinases/biosynthesis ; Mice ; Mice, Inbred DBA ; Oxidation-Reduction/drug effects ; Oxidative Stress/drug effects* ; Oxidative Stress/physiology
type II collagen–induced arthritis ; tumor necrosis factor-α (TNF-α) ; interleukin-1β (IL-1β) ; matrix metalloproteinase (MMP) ; oxidative damage
Plant-derived compounds with potent anti-inflammatory activity have attracted a great deal of attention as a source for novel anti-arthritic agents with minimal side effects. We attempted to determine the anti-arthritic effects of orally administered honokiol isolated from Magnolia species. The oral administration of honokiol inhibited the progression and severity of type II collagen (CII)-induced arthritis (CIA) by reducing clinical arthritis scores and paw swelling. The histological analysis demonstrated preserved joint space; and the immunohistochemical data showed that the levels of interleukin (IL)-17, matrix metalloproteinase (MMP)-3, MMP-9, MMP-13, and receptor activator for nuclear factor-κB ligand, as well as nitrotyrosine formation, were substantially suppressed in the honokiol-treated CIA mice. The elevated serum levels of tumor necrosis factor-α and IL-1β in the CIA mice were also restored to control levels via honokiol treatment. In the CIA mice, honokiol inhibited CII- or lipopolysaccharide-stimulated cytokine secretion in spleen cells, as well as CII-stimulated spleen cell proliferation. Furthermore, honokiol treatment reduced CIA-induced oxidative damage in the liver and kidney tissues of CIA mice. Collectively, the oral administration of honokiol inhibited CIA development by reducing the production of pro-inflammatory cytokines, MMP expressions, and oxidative stress. Thus, honokiol is an attractive candidate for an anti-arthritic agent.
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2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ki Rim(김기림)
Park, Kwang Kyun(박광균)
Chung, Won Yoon(정원윤) ORCID logo https://orcid.org/0000-0001-8428-9005
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