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Nanocomposite Microspheres of PLGA/HA with Antibiotics for Injectable Bone-Graft Materials

Authors
 Seho Lee  ;  Kwang-Mahn Kim  ;  Yong-Keun Lee 
Citation
 TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Vol.7(5) : 561-565, 2010 
Journal Title
TISSUE ENGINEERING AND REGENERATIVE MEDICINE(조직공학과 재생의학)
ISSN
 1738-2696 
Issue Date
2010
Keywords
HA ; PLGA ; injectable ; antibiotic ; tetracycline
Abstract
This study investigated the possibility of an injectable bone substitute consisting of methylcellulose
aqueous solutions and poly lactide-co-glycolide acid/hydroxyapatite (PLGA/HA) composite microspheres containing
sustained releasing antibiotics. HA nanoparticles were synthesized by coprecipitation. PLGA/HA composite
microspheres were prepared by oil-in-water emulsion/solvent evaporation with tetracycline. They were mixed with
a 2% (w/v) aqueous solution of methylcellulose. The particle size of the composite microspheres increased linearly
with increasing PLGA concentration from 17.8±4.5 to 185.4±29.5 μm. As the size of PLGA/HA composite microspheres
increased, the content of tetracycline increased from 0.8% to 70.3%. The release rate of tetracycline
decreased with increasing size of the composite microspheres. Tetracycline exhibited a burst release with nearly
100% escape within 24 hrs when the PLGA concentration was less than 20%. Sustained continuous release until 2
weeks when PLGA content was 20%. The gelation temperature of methylcellulose can be adjusted to normal body
temperature when NaCl content exceeds 5%. PLGA/HA composite microspheres mixed with a methylcellulose
aqueous solution was easily and completely ejected through an 18G needle when the mixing ratio was below 100%.
Files in This Item:
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Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kwang Mahn(김광만) ORCID logo https://orcid.org/0000-0002-5235-0294
Lee, Yong Keun(이용근)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/102437
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