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Nanocomposite Microspheres of PLGA/HA with Antibiotics for Injectable Bone-Graft Materials
DC Field | Value | Language |
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dc.contributor.author | 김광만 | - |
dc.contributor.author | 이용근 | - |
dc.date.accessioned | 2015-04-23T17:25:28Z | - |
dc.date.available | 2015-04-23T17:25:28Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1738-2696 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/102437 | - |
dc.description.abstract | This study investigated the possibility of an injectable bone substitute consisting of methylcellulose aqueous solutions and poly lactide-co-glycolide acid/hydroxyapatite (PLGA/HA) composite microspheres containing sustained releasing antibiotics. HA nanoparticles were synthesized by coprecipitation. PLGA/HA composite microspheres were prepared by oil-in-water emulsion/solvent evaporation with tetracycline. They were mixed with a 2% (w/v) aqueous solution of methylcellulose. The particle size of the composite microspheres increased linearly with increasing PLGA concentration from 17.8±4.5 to 185.4±29.5 μm. As the size of PLGA/HA composite microspheres increased, the content of tetracycline increased from 0.8% to 70.3%. The release rate of tetracycline decreased with increasing size of the composite microspheres. Tetracycline exhibited a burst release with nearly 100% escape within 24 hrs when the PLGA concentration was less than 20%. Sustained continuous release until 2 weeks when PLGA content was 20%. The gelation temperature of methylcellulose can be adjusted to normal body temperature when NaCl content exceeds 5%. PLGA/HA composite microspheres mixed with a methylcellulose aqueous solution was easily and completely ejected through an 18G needle when the mixing ratio was below 100%. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 561~565 | - |
dc.relation.isPartOf | TISSUE ENGINEERING AND REGENERATIVE MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Nanocomposite Microspheres of PLGA/HA with Antibiotics for Injectable Bone-Graft Materials | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Dental Engineering (치과생체재료공학) | - |
dc.contributor.googleauthor | Seho Lee | - |
dc.contributor.googleauthor | Kwang-Mahn Kim | - |
dc.contributor.googleauthor | Yong-Keun Lee | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00312 | - |
dc.contributor.localId | A02976 | - |
dc.relation.journalcode | J02734 | - |
dc.identifier.eissn | 2212-5469 | - |
dc.subject.keyword | HA | - |
dc.subject.keyword | PLGA | - |
dc.subject.keyword | injectable | - |
dc.subject.keyword | antibiotic | - |
dc.subject.keyword | tetracycline | - |
dc.contributor.alternativeName | Kim, Kwang Mahn | - |
dc.contributor.alternativeName | Lee, Yong Keun | - |
dc.contributor.affiliatedAuthor | Kim, Kwang Mahn | - |
dc.contributor.affiliatedAuthor | Lee, Yong Keun | - |
dc.citation.volume | 7 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 561 | - |
dc.citation.endPage | 565 | - |
dc.identifier.bibliographicCitation | TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Vol.7(5) : 561-565, 2010 | - |
dc.identifier.rimsid | 57330 | - |
dc.type.rims | ART | - |
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