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Nanocomposite Microspheres of PLGA/HA with Antibiotics for Injectable Bone-Graft Materials

DC Field Value Language
dc.contributor.author김광만-
dc.contributor.author이용근-
dc.date.accessioned2015-04-23T17:25:28Z-
dc.date.available2015-04-23T17:25:28Z-
dc.date.issued2010-
dc.identifier.issn1738-2696-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/102437-
dc.description.abstractThis study investigated the possibility of an injectable bone substitute consisting of methylcellulose aqueous solutions and poly lactide-co-glycolide acid/hydroxyapatite (PLGA/HA) composite microspheres containing sustained releasing antibiotics. HA nanoparticles were synthesized by coprecipitation. PLGA/HA composite microspheres were prepared by oil-in-water emulsion/solvent evaporation with tetracycline. They were mixed with a 2% (w/v) aqueous solution of methylcellulose. The particle size of the composite microspheres increased linearly with increasing PLGA concentration from 17.8±4.5 to 185.4±29.5 μm. As the size of PLGA/HA composite microspheres increased, the content of tetracycline increased from 0.8% to 70.3%. The release rate of tetracycline decreased with increasing size of the composite microspheres. Tetracycline exhibited a burst release with nearly 100% escape within 24 hrs when the PLGA concentration was less than 20%. Sustained continuous release until 2 weeks when PLGA content was 20%. The gelation temperature of methylcellulose can be adjusted to normal body temperature when NaCl content exceeds 5%. PLGA/HA composite microspheres mixed with a methylcellulose aqueous solution was easily and completely ejected through an 18G needle when the mixing ratio was below 100%.-
dc.description.statementOfResponsibilityopen-
dc.format.extent561~565-
dc.relation.isPartOfTISSUE ENGINEERING AND REGENERATIVE MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleNanocomposite Microspheres of PLGA/HA with Antibiotics for Injectable Bone-Graft Materials-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Dental Engineering (치과생체재료공학)-
dc.contributor.googleauthorSeho Lee-
dc.contributor.googleauthorKwang-Mahn Kim-
dc.contributor.googleauthorYong-Keun Lee-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00312-
dc.contributor.localIdA02976-
dc.relation.journalcodeJ02734-
dc.identifier.eissn2212-5469-
dc.subject.keywordHA-
dc.subject.keywordPLGA-
dc.subject.keywordinjectable-
dc.subject.keywordantibiotic-
dc.subject.keywordtetracycline-
dc.contributor.alternativeNameKim, Kwang Mahn-
dc.contributor.alternativeNameLee, Yong Keun-
dc.contributor.affiliatedAuthorKim, Kwang Mahn-
dc.contributor.affiliatedAuthorLee, Yong Keun-
dc.citation.volume7-
dc.citation.number5-
dc.citation.startPage561-
dc.citation.endPage565-
dc.identifier.bibliographicCitationTISSUE ENGINEERING AND REGENERATIVE MEDICINE, Vol.7(5) : 561-565, 2010-
dc.identifier.rimsid57330-
dc.type.rimsART-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실) > 1. Journal Papers

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