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소아청소년 연령에서 발생한 2형 당뇨병의 항췌도 자가항체 유무에 따른 임상적 특성

Other Titles
 The Clinical Characteristics of Type 2 Diabetes Mellitus with and without beta-cell Autoantibody in Children and Adole 
Authors
 Min Chul Ji  ;  Hyun Wook Chae  ;  Ho-Seong Kim  ;  Duk Hee Kim 
Citation
 Journal of Korean Society of Pediatric Endocrinology (대한소아내분비학회지), Vol.15(2) : 93-99, 2010 
Journal Title
 Journal of Korean Society of Pediatric Endocrinology (대한소아내분비학회지) 
ISSN
 1226-2242 
Issue Date
2010
Keywords
Diabetes mellitus, type 2 ; Autoantibodies ; Child ; Adolescent
Abstract
PURPOSE: The aim of this study is to investigate the differences in clinical characteristics and disease process between autoantibody-positive and -negative patients with type 2 diabetes mellitus (DM). METHODS: We investigated 162 patients diagnosed as DM between January 2000 and July 2009. 120 were classified as type 1 and 42 as type 2 DM. The clinical and laboratory data were obtained from medical records, retrospectively. RESULTS: The age at diagnosis, average BMI and serum C-peptide levels were significantly higher in type 2 DM patients than in type 1 DM patients. Type 2 DM patients had a significantly higher family history of diabetes and less frequent ketonuria. There were no significant differences between autoantibody-positive and -negative type 2 DM patients in age at diagnosis, BMI, C-peptide levels, HbA1c levels or family history. During the follow-up period, C-peptide levels were lower in the autoantibody-positive group than in the autoantibody-negative group, while. HbA1c levels were higher in the autoantibody-positive group. However, these differences were not statistically significant. CONCLUSION: In autoantibody-positive type 2 DM patients, progressive loss of beta-cell function leads to reduced insulin secretion and poor glycemic control as the disease progresses, and some may be reclassified as slowly progressive type 1 DM. Ccntinued and careful follow-up is therefore needed
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Duk Hee(김덕희)
Kim, Ho Seong(김호성) ORCID logo https://orcid.org/0000-0003-1135-099X
Chae, Hyun Wook(채현욱) ORCID logo https://orcid.org/0000-0001-5016-8539
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/102427
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