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소아청소년 연령에서 발생한 2형 당뇨병의 항췌도 자가항체 유무에 따른 임상적 특성
DC Field | Value | Language |
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dc.contributor.author | 김덕희 | - |
dc.contributor.author | 김호성 | - |
dc.contributor.author | 채현욱 | - |
dc.date.accessioned | 2015-04-23T17:25:10Z | - |
dc.date.available | 2015-04-23T17:25:10Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1226-2242 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/102427 | - |
dc.description.abstract | PURPOSE: The aim of this study is to investigate the differences in clinical characteristics and disease process between autoantibody-positive and -negative patients with type 2 diabetes mellitus (DM). METHODS: We investigated 162 patients diagnosed as DM between January 2000 and July 2009. 120 were classified as type 1 and 42 as type 2 DM. The clinical and laboratory data were obtained from medical records, retrospectively. RESULTS: The age at diagnosis, average BMI and serum C-peptide levels were significantly higher in type 2 DM patients than in type 1 DM patients. Type 2 DM patients had a significantly higher family history of diabetes and less frequent ketonuria. There were no significant differences between autoantibody-positive and -negative type 2 DM patients in age at diagnosis, BMI, C-peptide levels, HbA1c levels or family history. During the follow-up period, C-peptide levels were lower in the autoantibody-positive group than in the autoantibody-negative group, while. HbA1c levels were higher in the autoantibody-positive group. However, these differences were not statistically significant. CONCLUSION: In autoantibody-positive type 2 DM patients, progressive loss of beta-cell function leads to reduced insulin secretion and poor glycemic control as the disease progresses, and some may be reclassified as slowly progressive type 1 DM. Ccntinued and careful follow-up is therefore needed | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 93~99 | - |
dc.relation.isPartOf | Journal of Korean Society of Pediatric Endocrinology (대한소아내분비학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 소아청소년 연령에서 발생한 2형 당뇨병의 항췌도 자가항체 유무에 따른 임상적 특성 | - |
dc.title.alternative | The Clinical Characteristics of Type 2 Diabetes Mellitus with and without beta-cell Autoantibody in Children and Adole | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학) | - |
dc.contributor.googleauthor | Min Chul Ji | - |
dc.contributor.googleauthor | Hyun Wook Chae | - |
dc.contributor.googleauthor | Ho-Seong Kim | - |
dc.contributor.googleauthor | Duk Hee Kim | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00378 | - |
dc.contributor.localId | A01184 | - |
dc.contributor.localId | A04026 | - |
dc.relation.journalcode | J01548 | - |
dc.subject.keyword | Diabetes mellitus, type 2 | - |
dc.subject.keyword | Autoantibodies | - |
dc.subject.keyword | Child | - |
dc.subject.keyword | Adolescent | - |
dc.contributor.alternativeName | Kim, Duk Hee | - |
dc.contributor.alternativeName | Kim, Ho Seong | - |
dc.contributor.alternativeName | Chae, Hyun Wook | - |
dc.contributor.affiliatedAuthor | Kim, Duk Hee | - |
dc.contributor.affiliatedAuthor | Kim, Ho Seong | - |
dc.contributor.affiliatedAuthor | Chae, Hyun Wook | - |
dc.citation.volume | 15 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 93 | - |
dc.citation.endPage | 99 | - |
dc.identifier.bibliographicCitation | Journal of Korean Society of Pediatric Endocrinology (대한소아내분비학회지), Vol.15(2) : 93-99, 2010 | - |
dc.identifier.rimsid | 57323 | - |
dc.type.rims | ART | - |
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