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Prevalence and diversity of carbapenemases among imipenem-nonsusceptible Acinetobacter isolates in Korea: emergence of a novel OXA-182.

Authors
 Chang-Ki Kim  ;  Yangsoon Lee  ;  Hyukmin Lee  ;  Gun-Jo Woo  ;  Wonkeun Song  ;  Mi-Na Kim  ;  Wee-Gyo Lee  ;  Seok Hoon Jeong  ;  Kyungwon Lee  ;  Yunsop Chon 
Citation
 DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, Vol.68(4) : 432-438, 2010 
Journal Title
 DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE 
ISSN
 0732-8893 
Issue Date
2010
MeSH
Acinetobacter/classification ; Acinetobacter/drug effects ; Acinetobacter/enzymology* ; Acinetobacter/isolation & purification ; Acinetobacter Infections/epidemiology* ; Acinetobacter Infections/microbiology ; Amino Acid Sequence ; Anti-Bacterial Agents/pharmacology* ; Bacterial Proteins/biosynthesis ; Bacterial Proteins/chemistry ; Bacterial Proteins/classification ; Bacterial Proteins/genetics* ; DNA, Bacterial/analysis ; DNA, Bacterial/genetics ; Drug Resistance, Bacterial/genetics* ; Genetic Variation ; Humans ; Imipenem/pharmacology* ; Microbial Sensitivity Tests ; Molecular Sequence Data ; Polymerase Chain Reaction/methods ; Prevalence ; Republic of Korea/epidemiology ; Species Specificity ; beta-Lactamases/biosynthesis ; beta-Lactamases/chemistry ; beta-Lactamases/classification ; beta-Lactamases/genetics*
Keywords
OXA carbapenemase ; OXA-182 ; Metallo-β-lactamase ; Acinetobacter baumannii ; Acinetobacter genomospecies ; Korea
Abstract
Increase in multidrug-resistant Acinetobacter poses a serious problem in Korea. In this study, 190 imipenem (IPM)-nonsusceptible (NS) Acinetobacter isolates from 12 Korean hospitals in 2007 were used to determine species, prevalence, and antimicrobial susceptibility of OXA carbapenemase- and metallo-β-lactamase (MBL)-producing isolates. bla(OXA)-₂₃-like and ISAba1-asssociated bla(OXA)-₅₁-like genes were detected in 80% and 12% of 178 IPM-NS Acinetobacter baumannii isolates, respectively. A novel bla(OXA)-₁₈₂ was detected in 12 IPM-NS A. baumannii isolates. Twelve out of 14 MBL-producing isolates were non-baumanniiAcinetobacter. A. baumannii isolates with OXA carbapenemase were more often resistant to aminoglycosides, ciprofloxacin, and tigecycline than non-baumannii Acinetobacter isolates with MBL. Identical pulsed- field gel electrophoresis patterns were observed in 89% of A. baumannii isolates with bla(OXA)-₂₃-like gene. In conclusion, extremely rapid increase of IPM-NS A. baumannii in previous Korean studies was mainly due to clonal spread of OXA-23-producing A. baumannii isolates. A novel OXA-182 emerged in Korea.
Full Text
http://www.sciencedirect.com/science/article/pii/S0732889310002889
DOI
10.1016/j.diagmicrobio.2010.07.014
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chang Ki(김창기)
Lee, Kyungwon(이경원) ORCID logo https://orcid.org/0000-0003-3788-2134
Lee, Yang Soon(이양순)
Lee, Hyuk Min(이혁민) ORCID logo https://orcid.org/0000-0002-8523-4126
Jeong, Seok Hoon(정석훈) ORCID logo https://orcid.org/0000-0001-9290-897X
Chong, Yun Sop(정윤섭)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/102422
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