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Cited 36 times in

Prevalence and diversity of carbapenemases among imipenem-nonsusceptible Acinetobacter isolates in Korea: emergence of a novel OXA-182.

DC FieldValueLanguage
dc.contributor.author김창기-
dc.contributor.author이경원-
dc.contributor.author이양순-
dc.contributor.author이혁민-
dc.contributor.author정석훈-
dc.contributor.author정윤섭-
dc.date.accessioned2015-04-23T17:25:00Z-
dc.date.available2015-04-23T17:25:00Z-
dc.date.issued2010-
dc.identifier.issn0732-8893-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/102422-
dc.description.abstractIncrease in multidrug-resistant Acinetobacter poses a serious problem in Korea. In this study, 190 imipenem (IPM)-nonsusceptible (NS) Acinetobacter isolates from 12 Korean hospitals in 2007 were used to determine species, prevalence, and antimicrobial susceptibility of OXA carbapenemase- and metallo-β-lactamase (MBL)-producing isolates. bla(OXA)-₂₃-like and ISAba1-asssociated bla(OXA)-₅₁-like genes were detected in 80% and 12% of 178 IPM-NS Acinetobacter baumannii isolates, respectively. A novel bla(OXA)-₁₈₂ was detected in 12 IPM-NS A. baumannii isolates. Twelve out of 14 MBL-producing isolates were non-baumanniiAcinetobacter. A. baumannii isolates with OXA carbapenemase were more often resistant to aminoglycosides, ciprofloxacin, and tigecycline than non-baumannii Acinetobacter isolates with MBL. Identical pulsed- field gel electrophoresis patterns were observed in 89% of A. baumannii isolates with bla(OXA)-₂₃-like gene. In conclusion, extremely rapid increase of IPM-NS A. baumannii in previous Korean studies was mainly due to clonal spread of OXA-23-producing A. baumannii isolates. A novel OXA-182 emerged in Korea.-
dc.description.statementOfResponsibilityopen-
dc.format.extent432~438-
dc.relation.isPartOfDIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAcinetobacter/classification-
dc.subject.MESHAcinetobacter/drug effects-
dc.subject.MESHAcinetobacter/enzymology*-
dc.subject.MESHAcinetobacter/isolation & purification-
dc.subject.MESHAcinetobacter Infections/epidemiology*-
dc.subject.MESHAcinetobacter Infections/microbiology-
dc.subject.MESHAmino Acid Sequence-
dc.subject.MESHAnti-Bacterial Agents/pharmacology*-
dc.subject.MESHBacterial Proteins/biosynthesis-
dc.subject.MESHBacterial Proteins/chemistry-
dc.subject.MESHBacterial Proteins/classification-
dc.subject.MESHBacterial Proteins/genetics*-
dc.subject.MESHDNA, Bacterial/analysis-
dc.subject.MESHDNA, Bacterial/genetics-
dc.subject.MESHDrug Resistance, Bacterial/genetics*-
dc.subject.MESHGenetic Variation-
dc.subject.MESHHumans-
dc.subject.MESHImipenem/pharmacology*-
dc.subject.MESHMicrobial Sensitivity Tests-
dc.subject.MESHMolecular Sequence Data-
dc.subject.MESHPolymerase Chain Reaction/methods-
dc.subject.MESHPrevalence-
dc.subject.MESHRepublic of Korea/epidemiology-
dc.subject.MESHSpecies Specificity-
dc.subject.MESHbeta-Lactamases/biosynthesis-
dc.subject.MESHbeta-Lactamases/chemistry-
dc.subject.MESHbeta-Lactamases/classification-
dc.subject.MESHbeta-Lactamases/genetics*-
dc.titlePrevalence and diversity of carbapenemases among imipenem-nonsusceptible Acinetobacter isolates in Korea: emergence of a novel OXA-182.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Laboratory Medicine (진단검사의학)-
dc.contributor.googleauthorChang-Ki Kim-
dc.contributor.googleauthorYangsoon Lee-
dc.contributor.googleauthorHyukmin Lee-
dc.contributor.googleauthorGun-Jo Woo-
dc.contributor.googleauthorWonkeun Song-
dc.contributor.googleauthorMi-Na Kim-
dc.contributor.googleauthorWee-Gyo Lee-
dc.contributor.googleauthorSeok Hoon Jeong-
dc.contributor.googleauthorKyungwon Lee-
dc.contributor.googleauthorYunsop Chon-
dc.identifier.doi10.1016/j.diagmicrobio.2010.07.014-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01038-
dc.contributor.localIdA02649-
dc.contributor.localIdA02947-
dc.contributor.localIdA03286-
dc.contributor.localIdA03619-
dc.contributor.localIdA03679-
dc.relation.journalcodeJ00731-
dc.identifier.eissn1879-0070-
dc.identifier.pmid20884158-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0732889310002889-
dc.subject.keywordOXA carbapenemase-
dc.subject.keywordOXA-182-
dc.subject.keywordMetallo-β-lactamase-
dc.subject.keywordAcinetobacter baumannii-
dc.subject.keywordAcinetobacter genomospecies-
dc.subject.keywordKorea-
dc.contributor.alternativeNameKim, Chang Ki-
dc.contributor.alternativeNameLee, Kyung Won-
dc.contributor.alternativeNameLee, Yang Soon-
dc.contributor.alternativeNameLee, Hyuk Min-
dc.contributor.alternativeNameJeong, Seok Hoon-
dc.contributor.alternativeNameChong, Yun Sop-
dc.contributor.affiliatedAuthorKim, Chang Ki-
dc.contributor.affiliatedAuthorLee, Kyung Won-
dc.contributor.affiliatedAuthorLee, Yang Soon-
dc.contributor.affiliatedAuthorLee, Hyuk Min-
dc.contributor.affiliatedAuthorJeong, Seok Hoon-
dc.contributor.affiliatedAuthorChong, Yun Sop-
dc.citation.volume68-
dc.citation.number4-
dc.citation.startPage432-
dc.citation.endPage438-
dc.identifier.bibliographicCitationDIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, Vol.68(4) : 432-438, 2010-
dc.identifier.rimsid57318-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers

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