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Melanocytoma of the optic disk in the Korean population

Authors
 Lee, Christopher S  ;  Bae, Jeong H  ;  Jeon, Ik H  ;  BYEON, SUK H  ;  KOH, HYOUNG J  ;  Lee, Sung C 
Citation
 RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, Vol.30(10) : 1714-1720, 2010 
Journal Title
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
ISSN
 0275-004X 
Issue Date
2010
MeSH
Adult ; Aged ; Asian Continental Ancestry Group/ethnology ; Female ; Fluorescein Angiography ; Humans ; Korea ; Male ; Middle Aged ; Nevus, Pigmented/ethnology ; Nevus, Pigmented/pathology* ; Optic Disk/pathology* ; Optic Nerve Neoplasms/ethnology ; Optic Nerve Neoplasms/pathology* ; Retrospective Studies ; Visual Acuity/physiology ; Young Adult
Keywords
melanocytoma ; magnocellular nevus ; transformation ; management
Abstract
PURPOSE: To report on the clinical features and the natural course of optic disk melanocytoma in the Korean population.

METHODS: A retrospective review of medical records was performed on 27 consecutive patients with optic disk melanocytoma. In cases with tumor enlargement, surface area and diameter of tumors were measured from fundus images using computer software.

RESULTS: The median age at diagnosis was 46 years with a slight female predominance (63%). The median tumor diameter and height were 3.1 mm and 1.9 mm, respectively. There were no cases with tumor-related visual loss for a median follow-up of 2 years. Tumor enlargement was observed in 4 of 21 patients (19%) that had follow-up of 1 year or more with no malignant transformation. The mean change of tumor surface area was 2.4 mm (52% increase), and the mean change of tumor diameter was 1.8 mm over a mean follow-up of 53 months in 4 cases with tumor growth. Only tumor vascularization on fluorescent angiography correlated with tumor growth (Log-rank test; P = 0.049). Kaplan-Meier survival estimated that the tumor growth was 0% at 1 year, 14% at 5 years, and 57% at 8 years.

CONCLUSION: Optic disk melanocytoma in the Korean population tends to be superiorly located in the optic disk, and visual prognosis was excellent. Periodic ocular examination is warranted because 57% of patients were estimated to show tumor enlargement by 8 years of follow-up
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00006982-201011000-00022&LSLINK=80&D=ovft
DOI
10.1097/IAE.0b013e3181dd0bd3
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Koh, Hyoung Jun(고형준) ORCID logo https://orcid.org/0000-0002-5932-8516
Bae, Jeong Hun(배정훈)
Byeon, Suk Ho(변석호) ORCID logo https://orcid.org/0000-0001-8101-0830
Lee, Sung Chul(이성철) ORCID logo https://orcid.org/0000-0001-9438-2385
Lee, Christopher Seungkyu(이승규) ORCID logo https://orcid.org/0000-0001-5054-9470
Jun, Ik Hyun(전익현) ORCID logo https://orcid.org/0000-0002-2160-1679
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/102398
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