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Influence of BDNF and COMT polymorphisms on emotional decision making

 Jee In Kang  ;  Kee Namkoong  ;  Ra Yeon Ha  ;  Kyungun Jhung  ;  Yang Tae Kim  ;  Se Joo Kim 
 NEUROPHARMACOLOGY, Vol.58(7) : 1109-1113, 2010 
Journal Title
Issue Date
Brain-Derived Neurotrophic Factor/genetics* ; Catechol O-Methyltransferase/genetics* ; Decision Making* ; Emotions* ; Female ; Gambling ; Genotype ; Humans ; Korea ; Male ; Neuropsychological Tests ; Polymorphism, Genetic* ; Sequence Analysis, DNA ; Young Adult
Iowa gambling task ; BDNF Val66Met ; COMT Val158Met ; Emotional decision making
Decision making is an important brain function. Although little is known about the genetic basis of decision making, it has been suggested that it is mediated by the modulation of neurotransmitter systems. We investigated how the BDNF Val66Met and COMT Val158Met polymorphisms affect emotional decision making using the Iowa Gambling Task (IGT). One hundred sixty-eight healthy Korean college students (93 males, 75 females) with a complete dataset were included in the data analysis. The IGT and genotyping for the polymorphisms of BDNF Val66Met and COMT Val158Met were performed. Both Met/Met and Val/Met of the BDNF Val66Met polymorphism were significantly associated with a lower mean score of blocks 3-5 of the IGT and with less improvement from block 1 to block 3-5 than the Val/Val. However, the BDNF was not significantly associated with the score of block 1, and the COMT Val158Met polymorphism produced no significant effect on IGT performance. No interaction effect was observed between the BDNF and the COMT for the IGT. These findings suggest the BDNF Val66Met may affect the emotional decision making performance
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1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Jee In(강지인) ORCID logo https://orcid.org/0000-0002-2818-7183
Kim, Se Joo(김세주) ORCID logo https://orcid.org/0000-0002-5438-8210
Namkoong, Kee(남궁기) ORCID logo https://orcid.org/0000-0003-1400-8057
Jhung, Kyung Un(정경운)
Ha, Ra Yeon(하라연)
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