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DNA typing for the identification of old skeletal remains from Korean War victims

Authors
 Hwan Young Lee  ;  Na Young Kim  ;  Myung Jin Park  ;  Jeong Eun Sim  ;  Woo Ick Yang  ;  Kyoung-Jin Shin 
Citation
 JOURNAL OF FORENSIC SCIENCES, Vol.55(6) : 1422-1429, 2010 
Journal Title
JOURNAL OF FORENSIC SCIENCES
ISSN
 0022-1198 
Issue Date
2010
MeSH
Chromosomes, Human, Y ; Complementarity Determining Regions/genetics ; DNA Fingerprinting/methods* ; DNA Primers ; DNA, Mitochondrial/genetics ; Female ; Genotype ; Humans ; Korean War ; Likelihood Functions ; Male ; Polymerase Chain Reaction ; Sequence Analysis, DNA ; Tandem Repeat Sequences
Keywords
forensic science ; DNA typing ; skeletal remains ; DNA extraction ; mitochondrial DNA ; autosomal short tandem repeat ; Y‐chromosomal short tandem repeat ; mini‐STR
Abstract
The identification of missing casualties of the Korean War (1950-1953) has been performed using mitochondrial DNA (mtDNA) profiles, but recent advances in DNA extraction techniques and approaches using smaller amplicons have significantly increased the possibility of obtaining DNA profiles from highly degraded skeletal remains. Therefore, 21 skeletal remains of Korean War victims and 24 samples from biological relatives of the supposed victims were selected based on circumstantial evidence and/or mtDNA-matching results and were analyzed to confirm the alleged relationship. Cumulative likelihood ratios were obtained from autosomal short tandem repeat, Y-chromosomal STR, and mtDNA-genotyping results, and mainly confirmed the alleged relationship with values over 10⁵. The present analysis emphasizes the value of mini- and Y-STR systems as well as an efficient DNA extraction method in DNA testing for the identification of old skeletal remains.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1556-4029.2010.01411.x/abstract
DOI
10.1111/j.1556-4029.2010.01411.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Forensic Medicine (법의학과) > 1. Journal Papers
Yonsei Authors
Kim, Na Young(김나영)
Park, Myung Jin(박명진)
Shin, Kyoung Jin(신경진) ORCID logo https://orcid.org/0000-0002-1059-9665
Sim, Jeong Eun(심정은)
Lee, Hwan Young(이환영)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/102333
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