혈관대체체용 Polyurethane 지지체의 Compliance Property 향상을 위한 연구(I) Improved Compliance of Polyurethane Scaffold for Vascular Graft Application: Preliminary Study

Abstract

In this study, we prepared solvent casting polyurethane films (sPU) and electrospun polyurethane films (ePU) to compare their compliance for providing better mechanical properties for vascular graft replacement. Mechanical properties of the prepared specimens showed that Young's modulus of each specimen was 0.037 N/m2 (ePU) and 0.035 N/m2(sPU). Deformation energy of ePU and sPU specimens were 0.00098600 (J) and 0.0020706 (J), respectively, and porcine's aorta was 0.00034845 (J). The ePU specimen showed closer value to that of porcine's aorta than that of sPU specimen's. That means the compliance of the ePU revealed closer value to the compliance of the porcine's aorta than that of the sPU specimen. For surface property of the specimens, the contact angle of the ePU (57.39° ± 1.84) was more hydrophilic than that of sPU (64.73° ± 1.56). However, human umbilical vein endothelial cells (HUVECs) attachment and proliferation tests showed better attachment and proliferation (more than 20%) for the sPU specmen rather than the ePU specimen. Conclusively, the PU film made by nano fiber can provide better compliance property but cytocompatibility was somewhat behind compared to solvent cast PU film.