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Mel-18, a mammalian Polycomb gene, regulates angiogenic gene expression of endothelial cells

Authors
 Ji-Hye Jung  ;  Hyun-Jung Choi  ;  Yong-Sun Maeng  ;  Jung-Yeon Choi  ;  Minhyung Kim  ;  Ja-Young Kwon  ;  Yong-Won Park  ;  Young-Myeong Kim  ;  Daehee Hwang  ;  Young-Guen Kwon 
Citation
 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.400(4) : 523-530, 2010 
Journal Title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
ISSN
 0006-291X 
Issue Date
2010
Keywords
Mel-18 ; Polycomb group gene ; Endothelial cells ; Differentiation ; Angiogenesis
Abstract
Mel-18 is a mammalian homolog of Polycomb group (PcG) genes. Microarray analysis revealed that Mel-18 expression was induced during endothelial progenitor cell (EPC) differentiation and correlates with the expression of EC-specific protein markers. Overexpression of Mel-18 promoted EPC differentiation and angiogenic activity of ECs. Accordingly, silencing Mel-18 inhibited EC migration and tube formation in vitro. Gene expression profiling showed that Mel-18 regulates angiogenic genes including kinase insert domain receptor (KDR), claudin 5, and angiopoietin-like 2. Our findings demonstrate, for the first time, that Mel-18 plays a significant role in the angiogenic function of ECs by regulating endothelial gene expression.
Full Text
http://www.sciencedirect.com/science/article/pii/S0006291X10015962
DOI
10.1016/j.bbrc.2010.08.086
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Ja Young(권자영) ORCID logo https://orcid.org/0000-0003-3009-6325
Kim, Young Myeong(김영명)
Park, Yong Won(박용원)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/102250
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