Cited 7 times in
Mel-18, a mammalian Polycomb gene, regulates angiogenic gene expression of endothelial cells
DC Field | Value | Language |
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dc.contributor.author | 권자영 | - |
dc.contributor.author | 김영명 | - |
dc.contributor.author | 박용원 | - |
dc.date.accessioned | 2015-04-23T17:19:37Z | - |
dc.date.available | 2015-04-23T17:19:37Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/102250 | - |
dc.description.abstract | Mel-18 is a mammalian homolog of Polycomb group (PcG) genes. Microarray analysis revealed that Mel-18 expression was induced during endothelial progenitor cell (EPC) differentiation and correlates with the expression of EC-specific protein markers. Overexpression of Mel-18 promoted EPC differentiation and angiogenic activity of ECs. Accordingly, silencing Mel-18 inhibited EC migration and tube formation in vitro. Gene expression profiling showed that Mel-18 regulates angiogenic genes including kinase insert domain receptor (KDR), claudin 5, and angiopoietin-like 2. Our findings demonstrate, for the first time, that Mel-18 plays a significant role in the angiogenic function of ECs by regulating endothelial gene expression. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 523~530 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Mel-18, a mammalian Polycomb gene, regulates angiogenic gene expression of endothelial cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Obstetrics & Gynecology (산부인과학) | - |
dc.contributor.googleauthor | Ji-Hye Jung | - |
dc.contributor.googleauthor | Hyun-Jung Choi | - |
dc.contributor.googleauthor | Yong-Sun Maeng | - |
dc.contributor.googleauthor | Jung-Yeon Choi | - |
dc.contributor.googleauthor | Minhyung Kim | - |
dc.contributor.googleauthor | Ja-Young Kwon | - |
dc.contributor.googleauthor | Yong-Won Park | - |
dc.contributor.googleauthor | Young-Myeong Kim | - |
dc.contributor.googleauthor | Daehee Hwang | - |
dc.contributor.googleauthor | Young-Guen Kwon | - |
dc.identifier.doi | 10.1016/j.bbrc.2010.08.086 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00246 | - |
dc.contributor.localId | A00704 | - |
dc.contributor.localId | A01581 | - |
dc.relation.journalcode | J00281 | - |
dc.identifier.eissn | 1090-2104 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0006291X10015962 | - |
dc.subject.keyword | Mel-18 | - |
dc.subject.keyword | Polycomb group gene | - |
dc.subject.keyword | Endothelial cells | - |
dc.subject.keyword | Differentiation | - |
dc.subject.keyword | Angiogenesis | - |
dc.contributor.alternativeName | Kwon, Ja Young | - |
dc.contributor.alternativeName | Kim, Young Myeong | - |
dc.contributor.alternativeName | Park, Yong Won | - |
dc.contributor.affiliatedAuthor | Kwon, Ja Young | - |
dc.contributor.affiliatedAuthor | Kim, Young Myeong | - |
dc.contributor.affiliatedAuthor | Park, Yong Won | - |
dc.citation.volume | 400 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 523 | - |
dc.citation.endPage | 530 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.400(4) : 523-530, 2010 | - |
dc.identifier.rimsid | 51163 | - |
dc.type.rims | ART | - |
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