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The impact of steatosis on liver stiffness measurement in patients with chronic hepatitis B.

Authors
 Seung Up Kim  ;  Do Young Kim  ;  Sang Hoon Ahn  ;  Hee Man Kim  ;  Jung Min Lee  ;  Chae Yoon Chon  ;  Young Nyun Park  ;  Han Kwang-Hyub  ;  Jun Yong Park 
Citation
 HEPATO-GASTROENTEROLOGY, Vol.57(101) : 832-838, 2010 
Journal Title
 HEPATO-GASTROENTEROLOGY 
ISSN
 0172-6390 
Issue Date
2010
MeSH
Adult ; Comorbidity ; Elasticity ; Fatty Liver/epidemiology ; Fatty Liver/pathology* ; Female ; Hepatitis B, Chronic/epidemiology ; Hepatitis B, Chronic/pathology* ; Humans ; Linear Models ; Liver/pathology* ; Male ; Middle Aged ; Multivariate Analysis ; Prospective Studies
Abstract
BACKGROUND/AIMS: Recently, several studies have indicated that liver stiffness measurement (LSM) using FibroScan accurately predicts liver fibrosis. This study investigated the impact of steatosis on LSM in patients with chronic hepatitis B (CHB). METHODOLOGY: The study prospectively enrolled 162 patients (106 men and 56 women) with CHB who underwent both a liver biopsy and LSM between January 2005 and June 2008. We examined the overall univariate correlation between steatosis and LSM value and also performed a multivariate regression analysis to identify independent variables influencing LSM values. RESULTS: The mean age of the patients was 44.4 years and the mean body mass index was 23.3 +/- 2.8kg/m2. The fibrosis stage ranged from F1 to F4 in 16 patients (9.9%), 37 (22.8%), 17 (10.5%) and 92 (56.8%), respectively. Steatosis was S0 in 128 patients (79.0%), S1 in 28 (17.3%), S2 in 6 (3.7%) and S3 in none. No overall significant correlation was noted between LSM value and steatosis (r = 0.023, p = 0.770). In the multivariate linear regression analysis, only fibrosis stage showed statistical significance (r = 0.268, p < 0.001), while steatosis did not (r = 0.013, p = 0.841). CONCLUSIONS: Our findings suggest that mild to moderate steatosis does not have a significant impact on LSM values in patients with CHB.
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Do Young(김도영)
Kim, Seung Up(김승업) ORCID logo https://orcid.org/0000-0002-9658-8050
Kim, Hee Man(김희만)
Park, Young Nyun(박영년) ORCID logo https://orcid.org/0000-0003-0357-7967
Park, Jun Yong(박준용) ORCID logo https://orcid.org/0000-0001-6324-2224
Ahn, Sang Hoon(안상훈) ORCID logo https://orcid.org/0000-0002-3629-4624
Lee, Jung Min(이중민)
Chon, Chae Yoon(전재윤)
Han, Kwang-Hyub(한광협) ORCID logo https://orcid.org/0000-0003-3960-6539
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/102186
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