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경증 및 중등도의 한국인 여드름 환자에서 1% Nadifloxacin 크림(Nadixa(R))의 유효성 및 안전성 평가

Other Titles
 Clinical Efficacy and Tolerance of 1% Nadifloxacin Cream in the Treatment of Mild to Moderate Acne Vulgaris in South Korea 
Authors
 최원준  ;  김광중  ;  김낙인  ;  계영철  ;  서대헌  ;  이주흥  ;  김명남  ;  이은소  ;  이주희  ;  노영석 
Citation
 Korean Journal of Dermatology (대한피부과학회지), Vol.48(8) : 665-671, 2010 
Journal Title
Korean Journal of Dermatology(대한피부과학회지)
ISSN
 4944-4739 
Issue Date
2010
Keywords
1% nadifloxacin cream ; Acne ; Treatment
Abstract
Background: Antimicrobials have been a mainstay of inflammatory acne treatment for more than 30 years. However, antibiotic-resistant propionibacteria had been isolated with increased frequency, and associated with failure to respond to antibiotic therapy. Objective: The aim of this study was to investigate the clinical efficacy and tolerance of 1% nadifloxacin cream. Methods: In the final analysis, 197 patients with mild to moderate facial acne vulgaris were enrolled. The patients were instructed to apply 1% nadifloxacin cream twice daily to the affected skin after washing the face. Following 2 and 4 weeks of treatment, patients were observed for clinical response: number of the acne lesions, Korea acne grading system (KAGS), global improvement, and occurrence of adverse reactions. Results: During 4 weeks of treatment, nadifloxacin caused significant reduction in the number of inflamed papulo-pustular lesions and open/closed comedones. In addition, significant reduction of KAGS was observed. About 96% of patients showed clinical improvement in the overall evaluation of the therapeutic effect by physicians. All reported adverse events were mild. Conclusion: This study shows that 1% nadifloxacin cream can be an effective and safe treatment for mild to moderate acne vulgaris.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Ju Hee(이주희) ORCID logo https://orcid.org/0000-0002-1739-5956
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/102168
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