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Molecular and clinical characteristics of hepatitis B virus in Korea

Authors
 Sang Hoon Ahn  ;  Lilly Yuen  ;  Kwang-Hyub Han  ;  Margaret Littlejohn  ;  Hye Young Chang  ;  Hans Damerow  ;  Anna Ayres  ;  Jeong Heo  ;  Stephen Locarnini  ;  Peter A. Revill 
Citation
 JOURNAL OF MEDICAL VIROLOGY, Vol.82(7) : 1126-1134, 2010 
Journal Title
JOURNAL OF MEDICAL VIROLOGY
ISSN
 0146-6615 
Issue Date
2010
MeSH
Aged ; Amino Acid Substitution ; Carcinoma, Hepatocellular/pathology* ; Disease Progression ; Female ; Genome, Viral ; Hepatitis B virus/classification ; Hepatitis B virus/genetics* ; Hepatitis B, Chronic/pathology* ; Hepatitis B, Chronic/virology* ; Humans ; Liver Cirrhosis/pathology* ; Liver Neoplasms/pathology* ; Male ; Middle Aged ; Molecular Sequence Data ; Phylogeny ; Republic of Korea ; Young Adult
Abstract
Korea is an endemic area of hepatitis B virus (HBV) infection but very little is known about the molecular characteristics of HBV isolates from Korean patients or the association with disease progression. The complete HBV genome sequences from 53 Korean patients with chronic hepatitis B, advanced cirrhosis, or hepatocellular carcinoma (HCC) were analyzed to identify (i) subgenotype distribution and genetic diversity and (ii) signature mutations associated with liver disease progression. With the exception of 1 patient infected with HBV/B, all 52 patients (98.1%) were infected with HBV/C, subgenotype C2. These strains were 98.4% identical and the frequency of amino acid substitutions occurring within key immunological epitopes increased with disease severity. A number of amino acid/nucleotide substitutions were associated with HCC, namely sR24K (HBsAg), SI126T (HBsAg), and pcA1846T (precore gene) mutations (P = 0.029, 0.001, and 0.008, respectively). HBV harboring deletions in the pre-S region were also associated with increased liver disease severity (chronic hepatitis B vs. cirrhosis, P = 0.040; chronic hepatitis B vs. HCC, P = 0.040). Despite the high degree of sequence conservation, several key HBV mutations were associated with disease progression. Prospective studies with larger cohorts of patients are required to evaluate further the clinical manifestation of HBV/C2 in Korea
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/jmv.21844/abstract
DOI
10.1002/jmv.21844
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Ahn, Sang Hoon(안상훈) ORCID logo https://orcid.org/0000-0002-3629-4624
Chang, Hye Young(장혜영)
Han, Kwang-Hyub(한광협) ORCID logo https://orcid.org/0000-0003-3960-6539
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/102135
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