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Mechanical property characterization of prostate cancer using a minimally motorized indenter in an ex vivo indentation experiment

 Bum-Mo Ahn  ;  Jung Kim  ;  Lorenzo Ian  ;  Kun-Ho Rha  ;  Hyung-Joo Kim 
 UROLOGY, Vol.76(4) : 1007-1011, 2010 
Journal Title
Issue Date
Adenocarcinoma/pathology* ; Adenocarcinoma/surgery ; Adult ; Aged ; Elastic Modulus* ; Equipment Design ; Humans ; Male ; Middle Aged ; Neoplasm Staging ; Prostate/pathology* ; Prostatectomy ; Prostatic Neoplasms/pathology* ; Prostatic Neoplasms/surgery ; Transducers, Pressure
OBJECTIVES: To measure the mechanical property of prostatic tissues using a minimally motorized indenter and to determine whether measurable differences in mechanical property exist between cancerous and noncancerous tissues in an ex vivo experiment.

METHODS: A total of 552 sites from 46 prostate specimens taken during radical prostatectomy underwent an indentation experiment with a minimally motorized indenter, and the elastic modulus (Young's modulus) of the tissue was estimated.

RESULTS: The mean elastic modulus of the regions containing cancer and noncancer was 24.1 ± 14.5 and 17.0 ± 9.0 kPa, respectively. In the noncancerous regions, the prostate was separated into 5 parts according to the post hoc test for comparing the elastic modulus between the 2 groups: part 1, lateral apex; part 2, medial apex; part 3, lateral-mid; part 4, lateral base; and part 5, medial-mid and medial base. In the regions containing cancer tissue, the prostate was also separated into 5 parts: part 1, lateral apex and medial apex; part 2, lateral-mid; part 3, lateral base; part 4, medial base; and part 5, medial-mid. The elastic modulus was greater in the tissue with a Gleason score of 8 than in the other tissue. The elastic modulus was significantly greater in the tissue with a tumor volume >5 cm(3) than in the other tissue.

CONCLUSIONS: We determined the elastic moduli of prostatic tissue as a quantitative and objective parameter according to the regions of the prostate, the presence of cancerous tissue, the tumor volume, and the Gleason score
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1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Rha, Koon Ho(나군호) ORCID logo https://orcid.org/0000-0001-8588-7584
Lorenzo, Enrique Ian(이안로렌조)
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