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Transcriptional regulation of glucose sensors in pancreatic β-cells and liver: an update

Authors
 Jin-Sik Bae  ;  Tae-Hyun Kim  ;  Mi-Young Kim  ;  Joo-Man Park  ;  Yong-Ho Ahn 
Citation
 SENSORS, Vol.10(5) : 5031-5053, 2010 
Journal Title
 SENSORS 
Issue Date
2010
MeSH
Animals ; Gene Expression Regulation* ; Glucokinase/genetics* ; Glucokinase/metabolism ; Glucose/metabolism* ; Glucose Transporter Type 2/genetics* ; Glucose Transporter Type 2/metabolism ; Humans ; Insulin-Secreting Cells/metabolism ; Liver/enzymology ; Liver/metabolism* ; Transcription, Genetic*
Keywords
glucokinase (GCK) ; glucose sensor ; liver ; pancreatic β-cell ; solute carrier family 2 (SLC2A2) ; transcription
Abstract
Pancreatic β-cells and the liver play a key role in glucose homeostasis. After a meal or in a state of hyperglycemia, glucose is transported into the β-cells or hepatocytes where it is metabolized. In the β-cells, glucose is metabolized to increase the ATP:ADP ratio, resulting in the secretion of insulin stored in the vesicle. In the hepatocytes, glucose is metabolized to CO(2), fatty acids or stored as glycogen. In these cells, solute carrier family 2 (SLC2A2) and glucokinase play a key role in sensing and uptaking glucose. Dysfunction of these proteins results in the hyperglycemia which is one of the characteristics of type 2 diabetes mellitus (T2DM). Thus, studies on the molecular mechanisms of their transcriptional regulations are important in understanding pathogenesis and combating T2DM. In this paper, we will review a recent update on the progress of gene regulation of glucose sensors in the liver and β-cells.
Files in This Item:
T201003366.pdf Download
DOI
10.3390/s100505031
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Mi Young(김미영)
Kim, Tae Hyun(김태현)
Park, Joo Man(박주만)
Bae, Jin Sik(배진식)
Ahn, Yong Ho(안용호) ORCID logo https://orcid.org/0000-0002-4133-0757
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/102122
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