242 343

Cited 25 times in

Transcriptional regulation of glucose sensors in pancreatic β-cells and liver: an update

DC FieldValueLanguage
dc.contributor.author김미영-
dc.contributor.author김태현-
dc.contributor.author박주만-
dc.contributor.author배진식-
dc.contributor.author안용호-
dc.date.accessioned2015-04-23T17:15:32Z-
dc.date.available2015-04-23T17:15:32Z-
dc.date.issued2010-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/102122-
dc.description.abstractPancreatic β-cells and the liver play a key role in glucose homeostasis. After a meal or in a state of hyperglycemia, glucose is transported into the β-cells or hepatocytes where it is metabolized. In the β-cells, glucose is metabolized to increase the ATP:ADP ratio, resulting in the secretion of insulin stored in the vesicle. In the hepatocytes, glucose is metabolized to CO(2), fatty acids or stored as glycogen. In these cells, solute carrier family 2 (SLC2A2) and glucokinase play a key role in sensing and uptaking glucose. Dysfunction of these proteins results in the hyperglycemia which is one of the characteristics of type 2 diabetes mellitus (T2DM). Thus, studies on the molecular mechanisms of their transcriptional regulations are important in understanding pathogenesis and combating T2DM. In this paper, we will review a recent update on the progress of gene regulation of glucose sensors in the liver and β-cells.-
dc.description.statementOfResponsibilityopen-
dc.format.extent5031~5053-
dc.relation.isPartOfSENSORS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHGene Expression Regulation*-
dc.subject.MESHGlucokinase/genetics*-
dc.subject.MESHGlucokinase/metabolism-
dc.subject.MESHGlucose/metabolism*-
dc.subject.MESHGlucose Transporter Type 2/genetics*-
dc.subject.MESHGlucose Transporter Type 2/metabolism-
dc.subject.MESHHumans-
dc.subject.MESHInsulin-Secreting Cells/metabolism-
dc.subject.MESHLiver/enzymology-
dc.subject.MESHLiver/metabolism*-
dc.subject.MESHTranscription, Genetic*-
dc.titleTranscriptional regulation of glucose sensors in pancreatic β-cells and liver: an update-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Biochemistry & Molecular Biology (생화학,분자생물학)-
dc.contributor.googleauthorJin-Sik Bae-
dc.contributor.googleauthorTae-Hyun Kim-
dc.contributor.googleauthorMi-Young Kim-
dc.contributor.googleauthorJoo-Man Park-
dc.contributor.googleauthorYong-Ho Ahn-
dc.identifier.doi10.3390/s100505031-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00446-
dc.contributor.localIdA01666-
dc.contributor.localIdA01809-
dc.contributor.localIdA02249-
dc.contributor.localIdA01081-
dc.relation.journalcodeJ03219-
dc.identifier.eissn1424-8220-
dc.identifier.pmid22399922-
dc.subject.keywordglucokinase (GCK)-
dc.subject.keywordglucose sensor-
dc.subject.keywordliver-
dc.subject.keywordpancreatic β-cell-
dc.subject.keywordsolute carrier family 2 (SLC2A2)-
dc.subject.keywordtranscription-
dc.contributor.alternativeNameKim, Mi Young-
dc.contributor.alternativeNameKim, Tae Hyun-
dc.contributor.alternativeNamePark, Joo Man-
dc.contributor.alternativeNameBae, Jin Sik-
dc.contributor.alternativeNameAhn, Yong Ho-
dc.contributor.affiliatedAuthorKim, Mi Young-
dc.contributor.affiliatedAuthorPark, Joo Man-
dc.contributor.affiliatedAuthorBae, Jin Sik-
dc.contributor.affiliatedAuthorAhn, Yong Ho-
dc.contributor.affiliatedAuthorKim, Tae Hyun-
dc.citation.volume10-
dc.citation.number5-
dc.citation.startPage5031-
dc.citation.endPage5053-
dc.identifier.bibliographicCitationSENSORS, Vol.10(5) : 5031-5053, 2010-
dc.identifier.rimsid49561-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.