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Relation between obesity and bone mineral density and vertebral fractures in Korean postmenopausal women

Authors
 Kyong-Chol Kim  ;  Dong-Hyuk Shin  ;  Sei-Young Lee  ;  Jee-Aee Im  ;  Duk-Chul Lee 
Citation
 YONSEI MEDICAL JOURNAL, Vol.51(6) : 857-863, 2010 
Journal Title
 YONSEI MEDICAL JOURNAL 
ISSN
 0513-5796 
Issue Date
2010
MeSH
Aged ; Blood Glucose/metabolism ; Body Composition ; Body Mass Index ; Body Weight ; Bone Density* ; Female ; Humans ; Middle Aged ; Obesity/complications* ; Obesity/diagnosis ; Overweight ; Postmenopause* ; Republic of Korea ; Risk Factors ; Spinal Fractures/complications* ; Spinal Fractures/diagnosis
Abstract
PURPOSE: The traditional belief that obesity is protective against osteoporosis has been questioned. Recent epidemiologic studies show that body fat itself may be a risk factor for osteoporosis and bone fractures. Accumulating evidence suggests that metabolic syndrome and the individual components of metabolic syndrome such as hypertension, increased triglycerides, and reduced high-density lipoprotein cholesterol are also risk factors for low bone mineral density. Using a cross sectional study design, we evaluated the associations between obesity or metabolic syndrome and bone mineral density (BMD) or vertebral fracture. MATERIALS AND METHODS: A total of 907 postmenopausal healthy female subjects, aged 60-79 years, were recruited from woman hospitals in Seoul, South Korea. BMD, vetebral fracture, bone markers, and body composition including body weight, body mass index (BMI), percentage body fat, and waist circumference were measured. RESULTS: After adjusting for age, smoking status, alcohol consumption, total calcium intake, and total energy intake, waist circumference was negatively related to BMD of all sites (lumbar BMD p = 0.037, all sites of femur BMD p < 0.001) whereas body weight was still positively related to BMD of all sites (p < 0.001). Percentage body fat and waist circumference were much higher in the fracture group than the non-fracture group (p = 0.0383, 0.082 respectively). Serum glucose levels were positively correlated to lumbar BMD (p = 0.016), femoral neck BMD (p = 0.0335), and femoral trochanter BMD (p = 0.0082). Serum high density lipoprotein cholesterol (HDLC) was positively related to femoral trochanter BMD (p = 0.0366) and was lower in the control group than the fracture group (p = 0.011). CONCLUSION: In contrast to the effect favorable body weight on bone mineral density, high percentage body fat and waist circumference are related to low BMD and a vertebral fracture. Some components of metabolic syndrome were related to BMD and a vertebral fracture
Files in This Item:
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DOI
10.3349/ymj.2010.51.6.857
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyong Chol(김경철)
Lee, Duk Chul(이덕철) ORCID logo https://orcid.org/0000-0001-9166-1813
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/102078
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