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Insulin resistance independently influences arterial stiffness in normoglycemic normotensive postmenopausal women

Authors
 Jong Suk Park  ;  Ji Sun Nam  ;  Min Ho Cho  ;  Jeong Seon Yoo  ;  Chul Woo Ahn  ;  Sun Ha Jee  ;  Hong Soo Lee  ;  Bong Soo Cha  ;  Kyung Rae Kim  ;  Hyun Chul Lee 
Citation
 MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY, Vol.17(4) : 779-784, 2010 
Journal Title
 MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY 
ISSN
 1072-3714 
Issue Date
2010
MeSH
Adiponectin/blood ; Age Factors ; Aged ; Aorta/physiology* ; Blood Flow Velocity/physiology* ; Blood Glucose/analysis ; Blood Pressure/physiology ; Body Mass Index ; Cholesterol, HDL/blood ; Female ; Homeostasis ; Humans ; Insulin Resistance/physiology* ; Obesity, Abdominal/physiopathology ; Postmenopause/physiology* ; Pulsatile Flow/physiology* ; Triglycerides/blood ; Waist Circumference
Abstract
OBJECTIVE: Cardiovascular disease risk increases after menopause, which may be related to insulin resistance, and arterial stiffness is a significant predictor of atherosclerosis. We investigated the relationships among insulin resistance, adiponectin, and arterial stiffness in normoglycemic normotensive postmenopausal women. METHODS: From 9,555 participants who had routine health checkups, 455 normoglycemic normotensive postmenopausal women were enrolled. Serum concentrations of glucose, total cholesterol, triglyceride (TG), and high-density lipoprotein cholesterol (HDL-C) and adiponectin were measured. Insulin resistance was estimated by the insulin resistance index of homeostasis model assessment (HOMA-IR). Pulse wave velocity (PWV) was evaluated to assess arterial stiffness. RESULTS: The women were stratified into three groups according to their HOMA-IR values, and comparisons were made among the three groups. There were significant differences in metabolic parameters between the groups. The mean age, body mass index, waist circumference, fasting plasma glucose, TG, systolic blood pressure (SBP), diastolic blood pressure (DBP), aortic PWV, and peripheral PWV increased sequentially with the degree of insulin resistance. Meanwhile, HDL-C and adiponectin levels decreased with the worsening of insulin resistance. Age, body mass index, fasting plasma glucose, TG, insulin, SBP, HOMA-IR, aortic PWV, and peripheral PWV were significantly higher in women with central obesity, and HDL-C and adiponectin were significantly lower in women with central obesity. Aortic PWV and peripheral PWV were significantly correlated with age, waist circumference, total cholesterol, SBP, DBP, insulin, and HOMA-IR, but adiponectin was not associated with PWV. The results of multiple regression analysis indicated that SBP, DBP, and insulin resistance were independently correlated with PWV. CONCLUSIONS: Insulin resistance was independently associated with PWV in normoglycemic normotensive postmenopausal women
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00042192-201017040-00020&LSLINK=80&D=ovft
DOI
10.1097/gme.0b013e3181cd3d60
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Rae(김경래)
Nam, Ji Sun(남지선) ORCID logo https://orcid.org/0000-0001-8655-5258
Park, Jong Suk(박종숙) ORCID logo https://orcid.org/0000-0002-5385-1373
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
Yoo, Jeong Seon(유정선)
Lee, Hyun Chul(이현철)
Cho, Min Ho(조민호)
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/102072
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