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Insulin resistance independently influences arterial stiffness in normoglycemic normotensive postmenopausal women

DC FieldValueLanguage
dc.contributor.author김경래-
dc.contributor.author남지선-
dc.contributor.author박종숙-
dc.contributor.author안철우-
dc.contributor.author유정선-
dc.contributor.author이현철-
dc.contributor.author조민호-
dc.contributor.author지선하-
dc.contributor.author차봉수-
dc.date.accessioned2015-04-23T17:13:56Z-
dc.date.available2015-04-23T17:13:56Z-
dc.date.issued2010-
dc.identifier.issn1072-3714-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/102072-
dc.description.abstractOBJECTIVE: Cardiovascular disease risk increases after menopause, which may be related to insulin resistance, and arterial stiffness is a significant predictor of atherosclerosis. We investigated the relationships among insulin resistance, adiponectin, and arterial stiffness in normoglycemic normotensive postmenopausal women. METHODS: From 9,555 participants who had routine health checkups, 455 normoglycemic normotensive postmenopausal women were enrolled. Serum concentrations of glucose, total cholesterol, triglyceride (TG), and high-density lipoprotein cholesterol (HDL-C) and adiponectin were measured. Insulin resistance was estimated by the insulin resistance index of homeostasis model assessment (HOMA-IR). Pulse wave velocity (PWV) was evaluated to assess arterial stiffness. RESULTS: The women were stratified into three groups according to their HOMA-IR values, and comparisons were made among the three groups. There were significant differences in metabolic parameters between the groups. The mean age, body mass index, waist circumference, fasting plasma glucose, TG, systolic blood pressure (SBP), diastolic blood pressure (DBP), aortic PWV, and peripheral PWV increased sequentially with the degree of insulin resistance. Meanwhile, HDL-C and adiponectin levels decreased with the worsening of insulin resistance. Age, body mass index, fasting plasma glucose, TG, insulin, SBP, HOMA-IR, aortic PWV, and peripheral PWV were significantly higher in women with central obesity, and HDL-C and adiponectin were significantly lower in women with central obesity. Aortic PWV and peripheral PWV were significantly correlated with age, waist circumference, total cholesterol, SBP, DBP, insulin, and HOMA-IR, but adiponectin was not associated with PWV. The results of multiple regression analysis indicated that SBP, DBP, and insulin resistance were independently correlated with PWV. CONCLUSIONS: Insulin resistance was independently associated with PWV in normoglycemic normotensive postmenopausal women-
dc.description.statementOfResponsibilityopen-
dc.format.extent779~784-
dc.relation.isPartOfMENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdiponectin/blood-
dc.subject.MESHAge Factors-
dc.subject.MESHAged-
dc.subject.MESHAorta/physiology*-
dc.subject.MESHBlood Flow Velocity/physiology*-
dc.subject.MESHBlood Glucose/analysis-
dc.subject.MESHBlood Pressure/physiology-
dc.subject.MESHBody Mass Index-
dc.subject.MESHCholesterol, HDL/blood-
dc.subject.MESHFemale-
dc.subject.MESHHomeostasis-
dc.subject.MESHHumans-
dc.subject.MESHInsulin Resistance/physiology*-
dc.subject.MESHObesity, Abdominal/physiopathology-
dc.subject.MESHPostmenopause/physiology*-
dc.subject.MESHPulsatile Flow/physiology*-
dc.subject.MESHTriglycerides/blood-
dc.subject.MESHWaist Circumference-
dc.titleInsulin resistance independently influences arterial stiffness in normoglycemic normotensive postmenopausal women-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorJong Suk Park-
dc.contributor.googleauthorJi Sun Nam-
dc.contributor.googleauthorMin Ho Cho-
dc.contributor.googleauthorJeong Seon Yoo-
dc.contributor.googleauthorChul Woo Ahn-
dc.contributor.googleauthorSun Ha Jee-
dc.contributor.googleauthorHong Soo Lee-
dc.contributor.googleauthorBong Soo Cha-
dc.contributor.googleauthorKyung Rae Kim-
dc.contributor.googleauthorHyun Chul Lee-
dc.identifier.doi10.1097/gme.0b013e3181cd3d60-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00294-
dc.contributor.localIdA01268-
dc.contributor.localIdA02270-
dc.contributor.localIdA02499-
dc.contributor.localIdA03301-
dc.contributor.localIdA03819-
dc.contributor.localIdA03965-
dc.contributor.localIdA03996-
dc.contributor.localIdA01660-
dc.relation.journalcodeJ02219-
dc.identifier.eissn1530-0374-
dc.identifier.pmid20215975-
dc.identifier.urlhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00042192-201017040-00020&LSLINK=80&D=ovft-
dc.contributor.alternativeNameKim, Kyung Rae-
dc.contributor.alternativeNameNam, Ji Sun-
dc.contributor.alternativeNamePark, Jong Suk-
dc.contributor.alternativeNameAhn, Chul Woo-
dc.contributor.alternativeNameYoo, Jeong Seon-
dc.contributor.alternativeNameLee, Hyun Chul-
dc.contributor.alternativeNameCho, Min Ho-
dc.contributor.alternativeNameJee, Sun Ha-
dc.contributor.alternativeNameCha, Bong Soo-
dc.contributor.affiliatedAuthorKim, Kyung Rae-
dc.contributor.affiliatedAuthorNam, Ji Sun-
dc.contributor.affiliatedAuthorAhn, Chul Woo-
dc.contributor.affiliatedAuthorYoo, Jeong Seon-
dc.contributor.affiliatedAuthorLee, Hyun Chul-
dc.contributor.affiliatedAuthorCho, Min Ho-
dc.contributor.affiliatedAuthorJee, Sun Ha-
dc.contributor.affiliatedAuthorCha, Bong Soo-
dc.contributor.affiliatedAuthorPark, Jong Suk-
dc.citation.volume17-
dc.citation.number4-
dc.citation.startPage779-
dc.citation.endPage784-
dc.identifier.bibliographicCitationMENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY, Vol.17(4) : 779-784, 2010-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers

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