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Macular thickness variations with sex, age, and axial length in healthy subjects: a spectral domain-optical coherence tomography study

Authors
 Won Kyung Song  ;  Sung Chul Lee  ;  Eun Suk Lee  ;  Chan Yun Kim  ;  Sung Soo Kim 
Citation
 INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol.51(8) : 3913-3918, 2010 
Journal Title
 INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 
ISSN
 0146-0404 
Issue Date
2010
MeSH
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Aging/physiology* ; Body Weights and Measures ; Cross-Sectional Studies ; Eye/anatomy & histology* ; Female ; Humans ; Macula Lutea/anatomy & histology* ; Male ; Middle Aged ; Reference Values ; Refractive Errors/pathology ; Sex Factors ; Tomography, Optical Coherence ; Young Adult
Abstract
PURPOSE: To assess the relationship between macular retinal thickness and volume and age, sex, and refractive error/axial length with spectral domain-optical coherence tomography (SD-OCT). METHODS: One randomly selected eye of 198 consecutive ophthalmically normal subjects (104 men, 94 women) between July 2008 and January 2009, with corrected visual acuities better than 20/30 were included in this cross-sectional study. Complete ophthalmic examination, axial length measurement with a laser interferometer, and macular cube 512 x 128 scan by SD-OCT were performed. RESULTS: The mean age was 55.6 +/- 16.4 years (range, 17-83), average refractive error was -2.17 +/- 4.82 (range, -23.50-3.75), and average axial length was 24.73 +/- 1.98 mm (range, 21.52-32.51). The central subfield thickness, average inner macular thickness, and overall macular volume were significantly lower in the female subjects (partial correlation: P = 0.009, P = 0.027, and P = 0.042, respectively). As age increased, average inner macular thickness, average outer macular thickness, overall average macular thickness, and macular volume decreased significantly (partial correlation: P = 0.002, P = 0.002, P = 0.002, and P = 0.000, respectively). Refractive error had no significant influence in partial correlation analysis. Axial length correlated negatively with average outer macular thickness, overall average macular thickness, and macular volume (partial correlation: P = 0.006, P = 0.044, and P = 0.003, respectively). CONCLUSIONS: In normal subjects, SD-OCT showed that retinal thickness is related to age, sex, and axial length, with regional variations
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sung Soo(김성수) ORCID logo https://orcid.org/0000-0002-0574-7993
Kim, Chan Yun(김찬윤) ORCID logo https://orcid.org/0000-0002-8373-9999
Song, Won Kyung(송원경)
Lee, Sung Chul(이성철) ORCID logo https://orcid.org/0000-0001-9438-2385
Lee, Eun Suk(이은석)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/102010
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