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Contribution of APOA5-1131C allele to the increased susceptibility of diabetes mellitus in association with higher triglyceride in Korean women.

Authors
 Ki Ho Lee  ;  Oh Yoen Kim  ;  Hyo Hee Lim  ;  Young Jin Lee  ;  Yangsoo Jang  ;  Jong Ho Lee 
Citation
 METABOLISM-CLINICAL AND EXPERIMENTAL, Vol.59(11) : 1583-1590, 2010 
Journal Title
METABOLISM-CLINICAL AND EXPERIMENTAL
ISSN
 0026-0495 
Issue Date
2010
MeSH
Alleles ; Apolipoprotein A-V ; Apolipoproteins A/genetics* ; Asian Continental Ancestry Group/genetics ; Blood Glucose ; Case-Control Studies ; Cholesterol, HDL/blood ; Diabetes Mellitus/epidemiology ; Diabetes Mellitus/etiology ; Diabetes Mellitus/genetics* ; Female ; Genetic Predisposition to Disease/epidemiology ; Genetic Predisposition to Disease/genetics* ; Genotype ; Humans ; Korea/epidemiology ; Odds Ratio ; Triglycerides/blood*
Abstract
Apolipoprotein A5 (APOA5) -1131C allele is associated with higher triglyceride, an independent cardiovascular risk factor and a commonly recognized lipid abnormality in diabetes mellitus (DM). We investigated the association of APOA5 -1131T>C or S19W with DM. Study subjects were all women and categorized into metabolically healthy controls (n = 2033) and DM subjects (n = 304). Association of APOA5 -1131T>C with DM was calculated by odds ratio (OR). Anthropometric parameters, fasting glucose, and lipid profiles were measured. C carriers, particularly those with CC homozygote, had higher triglyceride and lower high-density lipoprotein cholesterol in both healthy controls (P < .001 and P < .001) and DM patients (P = .002 and P = .006) after the adjustment for age, body mass index, menopause, smoking, and drinking. APOA5 -1131C allele was associated with an increased risk of DM (OR, 1.61 [95% confidence interval {CI}, 1.23-2.10]; P < .001) after adjustment for the above confounders. Further adjustment for fasting triglyceride or/and high-density lipoprotein cholesterol attenuated a little bit, but still significantly increased the risk of DM in C carriers (OR(2), 1.36 [95% CI, 1.02-1.80]; P = .035 and OR(3), 1.36 [95% CI, 1.032-1.79]; P = .029, respectively). Interestingly, C allele carriers in DM patients showed a positive correlation between fasting glucose and triglyceride after the adjustment (r = 0.172, P = .035). On the other hand, this significant correlation was not observed in healthy women. Regarding S19W, minor allele was not found in our study population from prescreening test. In conclusion, APOA5 -1131C allele may contribute to the increased susceptibility of DM in Korean women. In addition, positive correlation between fasting glucose and triglyceride in C carriers of DM patients suggested that C allele in hyperglycemic states may be more susceptible to the risk of cardiovascular disease.
Full Text
http://www.sciencedirect.com/science/article/pii/S0026049510000624
DOI
10.1016/j.metabol.2010.02.008
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/101966
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