Cited 22 times in
Contribution of APOA5-1131C allele to the increased susceptibility of diabetes mellitus in association with higher triglyceride in Korean women.
DC Field | Value | Language |
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dc.contributor.author | 장양수 | - |
dc.date.accessioned | 2015-04-23T17:10:36Z | - |
dc.date.available | 2015-04-23T17:10:36Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0026-0495 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/101966 | - |
dc.description.abstract | Apolipoprotein A5 (APOA5) -1131C allele is associated with higher triglyceride, an independent cardiovascular risk factor and a commonly recognized lipid abnormality in diabetes mellitus (DM). We investigated the association of APOA5 -1131T>C or S19W with DM. Study subjects were all women and categorized into metabolically healthy controls (n = 2033) and DM subjects (n = 304). Association of APOA5 -1131T>C with DM was calculated by odds ratio (OR). Anthropometric parameters, fasting glucose, and lipid profiles were measured. C carriers, particularly those with CC homozygote, had higher triglyceride and lower high-density lipoprotein cholesterol in both healthy controls (P < .001 and P < .001) and DM patients (P = .002 and P = .006) after the adjustment for age, body mass index, menopause, smoking, and drinking. APOA5 -1131C allele was associated with an increased risk of DM (OR, 1.61 [95% confidence interval {CI}, 1.23-2.10]; P < .001) after adjustment for the above confounders. Further adjustment for fasting triglyceride or/and high-density lipoprotein cholesterol attenuated a little bit, but still significantly increased the risk of DM in C carriers (OR(2), 1.36 [95% CI, 1.02-1.80]; P = .035 and OR(3), 1.36 [95% CI, 1.032-1.79]; P = .029, respectively). Interestingly, C allele carriers in DM patients showed a positive correlation between fasting glucose and triglyceride after the adjustment (r = 0.172, P = .035). On the other hand, this significant correlation was not observed in healthy women. Regarding S19W, minor allele was not found in our study population from prescreening test. In conclusion, APOA5 -1131C allele may contribute to the increased susceptibility of DM in Korean women. In addition, positive correlation between fasting glucose and triglyceride in C carriers of DM patients suggested that C allele in hyperglycemic states may be more susceptible to the risk of cardiovascular disease. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1583~1590 | - |
dc.relation.isPartOf | METABOLISM-CLINICAL AND EXPERIMENTAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Alleles | - |
dc.subject.MESH | Apolipoprotein A-V | - |
dc.subject.MESH | Apolipoproteins A/genetics* | - |
dc.subject.MESH | Asian Continental Ancestry Group/genetics | - |
dc.subject.MESH | Blood Glucose | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Cholesterol, HDL/blood | - |
dc.subject.MESH | Diabetes Mellitus/epidemiology | - |
dc.subject.MESH | Diabetes Mellitus/etiology | - |
dc.subject.MESH | Diabetes Mellitus/genetics* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Genetic Predisposition to Disease/epidemiology | - |
dc.subject.MESH | Genetic Predisposition to Disease/genetics* | - |
dc.subject.MESH | Genotype | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Korea/epidemiology | - |
dc.subject.MESH | Odds Ratio | - |
dc.subject.MESH | Triglycerides/blood* | - |
dc.title | Contribution of APOA5-1131C allele to the increased susceptibility of diabetes mellitus in association with higher triglyceride in Korean women. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Ki Ho Lee | - |
dc.contributor.googleauthor | Oh Yoen Kim | - |
dc.contributor.googleauthor | Hyo Hee Lim | - |
dc.contributor.googleauthor | Young Jin Lee | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.contributor.googleauthor | Jong Ho Lee | - |
dc.identifier.doi | 10.1016/j.metabol.2010.02.008 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03448 | - |
dc.relation.journalcode | J02223 | - |
dc.identifier.eissn | 1532-8600 | - |
dc.identifier.pmid | 20303129 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0026049510000624 | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.citation.volume | 59 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1583 | - |
dc.citation.endPage | 1590 | - |
dc.identifier.bibliographicCitation | METABOLISM-CLINICAL AND EXPERIMENTAL, Vol.59(11) : 1583-1590, 2010 | - |
dc.identifier.rimsid | 50977 | - |
dc.type.rims | ART | - |
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