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Serum osteocalcin is related to abdominal obesity in Korean obese and overweight men

Authors
 Sang-Hwan Kim  ;  Ji-Won Lee  ;  Jee-Aee Im  ;  Hee-Jin Hwang 
Citation
 CLINICA CHIMICA ACTA, Vol.411(23-24) : 2054-2057, 2010 
Journal Title
CLINICA CHIMICA ACTA
ISSN
 0009-8981 
Issue Date
2010
MeSH
Adult ; Aged ; Asian Continental Ancestry Group* ; Body Composition ; Glucose/metabolism ; Humans ; Male ; Middle Aged ; Multivariate Analysis ; Obesity, Abdominal/blood* ; Obesity, Abdominal/diagnostic imaging ; Obesity, Abdominal/metabolism ; Osteocalcin/blood* ; Tomography, X-Ray Computed ; Young Adult
Keywords
Obesity ; Osteocalcin ; Visceral obesity ; Bone metabolism ; Male
Abstract
BACKGROUND: Growing evidence suggests a link between body composition and serum osteocalcin. Here we examined such an association between serum osteocalcin and body composition in Korean obese men.

METHODS: Eighty-six men, aged 20 to 76 years, who visited the obesity clinic at the Division of Family Medicine, Severance hospital, Seoul, Korea were recruited for this study. Abdominal fat computed tomography (CT) scans were performed to measure the visceral fat area (VFA) and subcutaneous fat area (SFA).

RESULTS: Serum osteocalcin levels were negatively correlated with age, VFA, and VFA/SFA ratio. In addition, serum osteocalcin levels were significantly decreased in obese and overweight subjects with visceral obesity (12.7±3.2) compared to those without visceral obesity (18.6±4.9). Multiple regression analysis showed that serum osteocalcin levels were associated with VFA in obese and overweight men after adjustment for age, insulin resistance, current smoking, alcohol consumption and adiposity indices.

CONCLUSION: Osteocalcin was inversely related to visceral obesity in Korean obese and overweight men. These results suggest cross-talk between bone and adipose tissue
Full Text
http://www.sciencedirect.com/science/article/pii/S000989811000567X
DOI
10.1016/j.cca.2010.08.046
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Ji Won(이지원) ORCID logo https://orcid.org/0000-0002-2666-4249
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/101937
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