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Preoperative nomograms for predicting extracapsular extension in Korean men with localized prostate cancer: a multi-institutional clinicopathologic study

Authors
 Jae Seung Chung  ;  Han Yong Choi  ;  Hae-Ryoung Song  ;  Seok-Soo Byun  ;  Seong il Seo  ;  Cheryn Song  ;  Jin Seon Cho  ;  Sang Eun Lee  ;  Hanjong Ahn  ;  Eun Sik Lee  ;  Won-Jae Kim  ;  Moon Kee Chung  ;  Tae Young Jung  ;  Ho Song Yu  ;  Young Deuk Choi 
Citation
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.25(10) : 1443-1448, 2010 
Journal Title
JOURNAL OF KOREAN MEDICAL SCIENCE
ISSN
 1011-8934 
Issue Date
2010
MeSH
Aged ; Area Under Curve ; Humans ; Logistic Models ; Male ; Middle Aged ; Nomograms ; Predictive Value of Tests ; Preoperative Period ; Prostate-Specific Antigen/blood ; Prostatectomy ; Prostatic Neoplasms/pathology* ; Prostatic Neoplasms/surgery ; Republic of Korea
Keywords
Nomograms ; Patient Selection ; Prostatectomy ; Prostatic neoplasms
Abstract
We developed a nomogram to predict the probability of extracapsular extension (ECE) in localized prostate cancer and to determine when the neurovascular bundle (NVB) may be spared. Total 1,471 Korean men who underwent radical prostatectomy for prostate cancer between 1995 and 2008 were included. We drew nonrandom samples of 1,031 for nomogram development, leaving 440 samples for nomogram validation. With multivariate logistic regression analyses, we made a nomogram to predicts the ECE probability at radical prostatectomy. Receiver operating characteristic (ROC) analyses were also performed to assess the predictive value of each variable alone and in combination. The internal validation was performed from 200 bootstrap re-samples and the external validation was also performed from the another cohort. Overall, 314 patients (30.5%) had ECE. Age, Prostate specific antigen (PSA), biopsy Gleason score, positive core ratio, and maximum percentage of biopsy tumor were independent predictors of the presence of ECE (all P values <0.05). The nomogram predicted ECE with good discrimination (an area under the ROC curve of 0.777). Our nomogram allows for the preoperative identification of patients with an ECE and may prove useful in selecting patients to receive nerve sparing radical prostatectomy
Files in This Item:
T201002940.pdf Download
DOI
10.3346/jkms.2010.25.10.1443
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Song, Hae Ryoung(송혜령)
Yu, Ho Song(유호송)
Choi, Young Deuk(최영득) ORCID logo https://orcid.org/0000-0002-8545-5797
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/101912
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