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Association of estrogen receptor-alpha gene polymorphism with pathogenesis of osteoporosis in Korean vegetarian men

Authors
 Kim S.Y.  ;  Kim H.H.  ;  Nam C.M.  ;  Kim H.C.  ;  Suh I.  ;  Kang B.Y. 
Citation
 MEDICAL PRINCIPLES AND PRACTICE, Vol.19(3) : 200-205, 2010 
Journal Title
 MEDICAL PRINCIPLES AND PRACTICE 
ISSN
 1011-7571 
Issue Date
2010
MeSH
Adult ; Aged ; Aged, 80 and over ; Asian Continental Ancestry Group ; Body Mass Index ; Calcaneus/diagnostic imaging* ; Diet, Vegetarian* ; Estrogen Receptor alpha/genetics* ; Genetic Association Studies ; Genotype ; Humans ; Korea/epidemiology ; Male ; Middle Aged ; Osteoporosis/diagnostic imaging ; Osteoporosis/genetics* ; Polymorphism, Restriction Fragment Length ; Ultrasonography
Keywords
Calcaneus ; ER1 gene ; Male gender ; Polymorphism ; Quantitative ultrasound
Abstract
OBJECTIVE: The purpose of this study was to investigate the association between two genetic polymorphisms (PvuII and XbaI restriction fragment length polymorphisms, RFLPs) of the estrogen receptor-alpha (ER1) gene and the quantitative ultrasound (QUS) parameters at the calcaneus. Subjects and METHODS: Two hundred and sixty-six Korean vegetarian men, mean age 50.9+/-12.0 years (range 26-80), were studied. Polymorphisms at the ER1 gene sites and the cross-sectional associates of genetic factors with calcaneal QUS parameters including broadband ultrasound attenuation (BUA) and the speed of sound (SOS) were analyzed by RFLPs using polymerase chain reaction. RESULTS: The distribution of PvuII and XbaI RFLPs in the ER1 gene was as follows: PP 11.6%, Pp 47.2%, pp 41.2%, XX 1.2%, Xx 24.4% and xx 74.4%. After adjusting for potential confounding factors such as age and body mass index, two genetic polymorphisms of the ER1 gene were independently associated with BUA, SOS and stiffness index at the calcaneus of our subjects. The QUS measurements of the subjects with the xx genotype were higher than those of the subjects with an Xx genotype, while the QUS measurements of the subjects with a Pp genotype were significantly lower than those of the subjects with PP or pp genotypes (p<0.05). CONCLUSION: The results suggest that the PvuII and XbaI RFLPs of the ER1 gene may be genetic factors that affect QUS at the calcaneus
Full Text
http://www.karger.com/Article/FullText/285288
DOI
10.1159/000285288
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyeon Chang(김현창) ORCID logo https://orcid.org/0000-0001-7867-1240
Nam, Chung Mo(남정모) ORCID logo https://orcid.org/0000-0003-0985-0928
Suh, Il(서일) ORCID logo https://orcid.org/0000-0002-9689-7849
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/101891
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