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Clinical features and follow-up results of pulsating polypoidal choroidal vasculopathy treated with photodynamic therapy

 Suk Ho Byeon  ;  Young Ju Lew  ;  Sung Chul Lee  ;  Oh Woong Kwon 
 ACTA OPHTHALMOLOGICA, Vol.88(6) : 660-668, 2010 
Journal Title
Issue Date
Aged ; Aged, 80 and over ; Choroid/blood supply* ; Choroid Diseases/diagnosis* ; Choroid Diseases/drug therapy* ; Choroid Diseases/physiopathology ; Coloring Agents ; Female ; Fluorescein Angiography ; Follow-Up Studies ; Humans ; Indocyanine Green ; Male ; Middle Aged ; Peripheral Vascular Diseases/diagnosis* ; Peripheral Vascular Diseases/drug therapy* ; Peripheral Vascular Diseases/physiopathology ; Photochemotherapy* ; Prognosis ; Pulsatile Flow ; Retinal Hemorrhage/physiopathology ; Retrospective Studies ; Visual Acuity/physiology
haemorrhage ; photodynamic therapy (PDT) ; polypoidal choroidal vasculopathy (PCV) ; pulsatile blood flow ; pulsation
PURPOSE:  To report on the clinical course of pulsating polypoidal choroidal vasculopathy (PCV) treated with photodynamic therapy (PDT). METHODS:   A total of 63 eyes of 58 consecutive patients diagnosed with PCV, treated with PDT and followed up for at least 6months were enrolled. Best-corrected visual acuity (BCVA), fluorescein angiography and high-speed indocyanine green angiography (ICGA) using confocal scanning laser ophthalmoscopy (HRA) were performed. RESULTS:   Of the 63 PCV eyes, 14 eyes (22.2%) of 14 patients were classified as having pulsating PCV. The mean age of pulsating PCV patients was 60.6±7.0years (48-69years), which was younger than non-pulsating PCV patients (65.7years, p=0.035). The mean follow-up period was 23.9±10.7months, and PDT was administered 1.6±0.9 times to pulsating PCV patients. The mean logMAR BCVAs were 0.85±0.47 at presentation and 0.71±0.52 at final examination. Extensive haemorrhagic events were more common in pulsating than in non-pulsating PCV patients (57.1% versus 26.5%, p=0.032). However, the risk of haemorrhage within 3months of PDT was similar for both pulsating PCV and the remaining patients (14.3% versus 20%, p=0.723). CONCLUSION:   Pulsating PCV showed distinctive features including a relatively younger patient age at presentation, and a haemorrhagic tendency (especially extensive). However, the use of PDT did not directly increase the risk of haemorrhage in pulsating PCV patients.
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1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Oh Woong(권오웅)
Byeon, Suk Ho(변석호) ORCID logo https://orcid.org/0000-0001-8101-0830
Lew, Young Ju(유영주)
Lee, Sung Chul(이성철) ORCID logo https://orcid.org/0000-0001-9438-2385
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