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Comparison of therapeutic efficacy between bortezomib and combination treatment of prednisolone and mycophenolate mofetil on nephritis in NZB/WF1 mice.

Authors
 S. Lee  ;  B. Kim 
Citation
 CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, Vol.28(3) : 393-396, 2010 
Journal Title
 CLINICAL AND EXPERIMENTAL RHEUMATOLOGY 
ISSN
 0392-856X 
Issue Date
2010
MeSH
Animals ; Boronic Acids/pharmacology* ; Bortezomib ; Cell Division ; Disease Models, Animal ; Drug Therapy, Combination ; Female ; Glucocorticoids/pharmacology ; Immunoglobulin G/metabolism ; Immunosuppressive Agents/pharmacology ; Kidney Glomerulus/immunology ; Kidney Glomerulus/pathology ; Lupus Nephritis/drug therapy* ; Lupus Nephritis/immunology ; Lupus Nephritis/pathology ; Mice ; Mice, Inbred NZB ; Mycophenolic Acid/analogs & derivatives* ; Mycophenolic Acid/pharmacology ; Prednisolone/pharmacology* ; Protease Inhibitors/pharmacology ; Proteinuria/drug therapy ; Proteinuria/immunology ; Proteinuria/pathology ; Pyrazines/pharmacology*
Keywords
Bortezomib ; lupus nephritis ; NZB/WF1 mice
Abstract
OBJECTIVES: We investigated the efficacy of bortezomib on nephritis in NZB/WF1 mice, and compared it to prednisolone (PL) and mycophenolate mofetil (MMF) treatment. METHODS: Twenty-three NZB/WF1 mice were divided into four groups (untreated, 0.1 mg/kg and 1 mg/kg bortezomib-treated, and PL plus MMF-treated). Proteinuria, glomerular IgG deposition, cellular proliferation and histologic damages were evaluated. RESULTS: In comparison with the untreated mice, 1 mg/kg bortezomib significantly reduced proteinuria and attenuated glomerular IgG deposition, cellular proliferation and histologic damages similar to PL plus MMF. 0.1 mg/kg bortezomib significantly improved glomerular IgG deposition and histologic damages except proteinuria or cellular proliferation compared to untreated mice. PL plus MMF showed significantly greater inhibition of cellular proliferation and histologic damage than 1 mg/kg bortezomib. CONCLUSIONS: We found that 1 mg/kg bortezomib significantly improved lupus nephritis in NZB/WF1 mice. However, its efficacy did not exceed PL plus MMF treatment.
Full Text
http://www.clinexprheumatol.org/abstract.asp?a=595
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Beom Seok(김범석) ORCID logo https://orcid.org/0000-0002-5732-2583
Lee, Sang Won(이상원) ORCID logo https://orcid.org/0000-0002-8038-3341
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/101838
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