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한국인 성인 Henoch-Schönlein Purpura 환자의 임상적 특징

Other Titles
 Clinical Manifestations of Korean Adult Patients with Henoch-Schonlein Purpura 
 강 윤  ;  하유정  ;  이광훈  ;  정상윤  ;  이상원  ;  이수곤  ;  박용범 
 Journal of the Korean Rheumatism Association (대한류마티스학회지), Vol.17(2) : 133-142, 2010 
Journal Title
 Journal of the Korean Rheumatism Association (대한류마티스학회지) 
Issue Date
Henoch-Schönlein Purpura ; Adult ; Clinical manifestation ; Prognosis ; Chronic renal failure
OBJECTIVE: We investigated the clinical data and analyzed the significant prognostic factors for outcomes in Korean adult patients with Henoch-Schonlein Purpura (HSP). METHODS: We retrospectively reviewed the medical records of 52 patients over 20 years-old, who visited the Yonsei University Severance Hospital from December 1999 to November 2009, and fulfilled the classification criteria for HSP. We investigated the epidemiologic data, clinical features, renal biopsy findings, laboratory results and disease outcomes. RESULTS: The median age was 43.5 (20~83) years old and 29 out of 52 patients (55.8%) were male. HSP exhibited seasonal variation and most frequently developed in winter (42.3%), followed by spring (25.0%). Upper respiratory infection was the most common known preceding event for HSP development. Skin manifestations were observed in all subjects, followed by kidney (80.8%), gastro-intestine (57.7%) and joints (26.9%). After a median follow-up period 14.5 (1~227) months, 12 patients experienced HSP relapse (23.1%), and 7 patients had chronic renal failure (13.4%). Univariate analysis showed that renal insufficiency (p=0.002) and nephritic syndrome (p=0.026) at diagnosis were significantly related to the development of chronic renal failure. Of the two parameters, only initial renal insufficiency was found to be a significant predictive value for chronic renal failure (OR=28.7, p=0.001, 95% confidential interval 3.6~225.3). CONCLUSION: Renal insufficiency at diagnosis may be a useful predictive factor for progression to chronic renal failure in Korean adult patients with HSP.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Yoon(강윤)
Park, Yong Beom(박용범)
Lee, Kwang Hoon(이광훈)
Lee, Sang Won(이상원) ORCID logo https://orcid.org/0000-0002-8038-3341
Lee, Soo Kon(이수곤)
Jung, Sang Youn(정상윤)
Ha, You Jung(하유정)
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