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Initial experiences with proton MR spectroscopy in treatment monitoring of mitochondrial encephalopathy

DC FieldValueLanguage
dc.contributor.author김진아-
dc.contributor.author김흥동-
dc.contributor.author이승구-
dc.contributor.author이영목-
dc.contributor.author이준수-
dc.date.accessioned2015-04-23T17:03:59Z-
dc.date.available2015-04-23T17:03:59Z-
dc.date.issued2010-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/101758-
dc.description.abstractPURPOSE: Mitochondrial encephalopathy (ME) is a rare disorder of energy metabolism. The disease course can roughly be evaluated by clinical findings. The purpose of this study was to evaluate metabolic spectral changes using proton MR spectroscopy (MRS), and to establish a way to monitor ME by neuroimaging. MATERIALS AND METHODS: Proton MRS data were retrospectively reviewed in 12 patients with muscle biopsy-confirmed ME (M : F = 7 : 5, Mean age = 4.8 years). All received 1H-MRS initially and also after a ketogenic diet and mitochondrial disease treatment cocktail (follow up average was 10.2 months). Changes of N-acetylaspartate/ creatine (NAA/Cr) ratio, choline/creatine (Cho/Cr) ratio, and lactate peak in basal ganglia at 1.2 ppm were evaluated before and after treatment. Findings on conventional T2 weighted MR images were also evaluated. RESULTS: On conventional MRI, increased basal ganglia T2 signal intensity was the most common finding with ME (n = 9, 75%), followed by diffuse cerebral atrophy (n = 8, 67%), T2 hyperintense lesions at pons and midbrain (n = 4, 33%), and brain atrophy (n = 2, 17%). Lactate peak was found in 4 patients; 2 had disappearance of the peak on follow up MRS. Quantitative analysis showed relative decrease of Cho/Cr ratio on follow up MRS (p = 0.0058, paired t-test, two-tailed). There was no significant change in NAA/Cr ratio. CONCLUSION: MRS is a useful tool for monitoring disease progression or improvement in ME, and decrease or disappearance of lactate peak and reduction of Cho/Cr fraction were correlated well with improvement of clinical symptoms.-
dc.description.statementOfResponsibilityopen-
dc.format.extent672~675-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHChild-
dc.subject.MESHChild, Preschool-
dc.subject.MESHCholine/metabolism-
dc.subject.MESHCreatine/metabolism-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHInfant-
dc.subject.MESHMagnetic Resonance Spectroscopy*-
dc.subject.MESHMale-
dc.subject.MESHMitochondrial Encephalomyopathies/pathology*-
dc.subject.MESHRetrospective Studies-
dc.titleInitial experiences with proton MR spectroscopy in treatment monitoring of mitochondrial encephalopathy-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아과학)-
dc.contributor.googleauthorSeung-Koo Lee-
dc.contributor.googleauthorJinna Kim-
dc.contributor.googleauthorHeung Dong Kim-
dc.contributor.googleauthorJoon Soo Lee-
dc.contributor.googleauthorYoung Mock Lee-
dc.identifier.doi10.3349/ymj.2010.51.5.672-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01022-
dc.contributor.localIdA01208-
dc.contributor.localIdA02912-
dc.contributor.localIdA02955-
dc.contributor.localIdA03177-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid20635440-
dc.subject.keywordMagnetic resonance spectroscopy-
dc.subject.keywordmitochondrial diseases-
dc.contributor.alternativeNameKim, Jinna-
dc.contributor.alternativeNameKim, Heung Dong-
dc.contributor.alternativeNameLee, Seung Koo-
dc.contributor.alternativeNameLee, Young Mock-
dc.contributor.alternativeNameLee, Joon Soo-
dc.contributor.affiliatedAuthorKim, Jinna-
dc.contributor.affiliatedAuthorKim, Heung Dong-
dc.contributor.affiliatedAuthorLee, Seung Koo-
dc.contributor.affiliatedAuthorLee, Young Mock-
dc.contributor.affiliatedAuthorLee, Joon Soo-
dc.citation.volume51-
dc.citation.number5-
dc.citation.startPage672-
dc.citation.endPage675-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.51(5) : 672-675, 2010-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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