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Cerebral glucose metabolism of Parkinson's disease patients with mild cognitive impairment

Authors
 Lyoo C.H.  ;  Jeong Y.  ;  Ryu Y.H.  ;  Rinne J.O.  ;  Lee M.S. 
Citation
 EUROPEAN NEUROLOGY, Vol.64(2) : 65-73, 2010 
Journal Title
 EUROPEAN NEUROLOGY 
ISSN
 0014-3022 
Issue Date
2010
MeSH
Aged ; Brain/diagnostic imaging* ; Brain/metabolism ; Brain Mapping ; Case-Control Studies ; Cerebral Cortex/diagnostic imaging* ; Cognition Disorders*/complications ; Cognition Disorders*/diagnostic imaging ; Cognition Disorders*/pathology ; Dementia/complications ; Dementia/diagnostic imaging ; Dementia/pathology ; Female ; Fluorodeoxyglucose F18 ; Humans ; Male ; Mental Status Schedule ; Middle Aged ; Neuropsychological Tests ; Parkinson Disease*/complications ; Parkinson Disease*/diagnostic imaging ; Parkinson Disease*/pathology ; Positron-Emission Tomography
Keywords
Parkinson’s disease ; Mild cognitive impairment ; Positron emission tomography
Abstract
BACKGROUND: Half of Parkinson's disease (PD) patients with mild cognitive impairment (MCI) develop dementia. We studied topographic distribution of cerebral hypometabolism in PD with different types of MCI. METHODS: This study included 61 nondemented PD patients and 14 age-matched controls. PD patients were grouped into normal cognition (PD-NC, n = 20), single amnestic (PD-SA, n = 12), single nonamnestic (PD-SN, n = 11), and multidomain MCI (PD-MD, n = 18). Using [(18)F]-fluorodeoxy-glucose PET, cerebral glucose metabolism of MCI groups was compared with that of controls and the PD-NC group. RESULTS: In comparison with controls, PD-NC and PD-SA groups showed no hypometabolic brain areas. However, the PD-SN group showed hypometabolism in parieto-temporo-occipital cortices. The PD-MD group showed widespread hypometabolism that predominantly involved parieto-occipital cortices. In comparison with the PD-NC group, only the PD-MD group showed hypometabolism in lateral frontal, cingulate, and parieto-temporo-occipital cortices. CONCLUSIONS: The distribution of hypometabolic brain areas of the PD-MD group suggests that PD-MD seems to be caused by a common pathology with PD dementia. PD-SA and PD-SN seem to be caused by very mild or topographically heterogeneous cerebral dysfunction. Longitudinal clinical and neuroimaging studies are needed to define whether PD patients with single domain MCI progress to PD-MD and finally to dementia
Full Text
http://www.karger.com/Article/FullText/315036
DOI
10.1159/000315036
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Lyoo, Chul Hyoung(류철형) ORCID logo https://orcid.org/0000-0003-2231-672X
Ryu, Young Hoon(유영훈) ORCID logo https://orcid.org/0000-0002-9000-5563
Lee, Myung Sik(이명식) ORCID logo https://orcid.org/0000-0002-8413-1854
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/101743
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