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Cerebral glucose metabolism of Parkinson's disease patients with mild cognitive impairment

DC FieldValueLanguage
dc.contributor.author류철형-
dc.contributor.author유영훈-
dc.contributor.author이명식-
dc.date.accessioned2015-04-23T17:03:31Z-
dc.date.available2015-04-23T17:03:31Z-
dc.date.issued2010-
dc.identifier.issn0014-3022-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/101743-
dc.description.abstractBACKGROUND: Half of Parkinson's disease (PD) patients with mild cognitive impairment (MCI) develop dementia. We studied topographic distribution of cerebral hypometabolism in PD with different types of MCI. METHODS: This study included 61 nondemented PD patients and 14 age-matched controls. PD patients were grouped into normal cognition (PD-NC, n = 20), single amnestic (PD-SA, n = 12), single nonamnestic (PD-SN, n = 11), and multidomain MCI (PD-MD, n = 18). Using [(18)F]-fluorodeoxy-glucose PET, cerebral glucose metabolism of MCI groups was compared with that of controls and the PD-NC group. RESULTS: In comparison with controls, PD-NC and PD-SA groups showed no hypometabolic brain areas. However, the PD-SN group showed hypometabolism in parieto-temporo-occipital cortices. The PD-MD group showed widespread hypometabolism that predominantly involved parieto-occipital cortices. In comparison with the PD-NC group, only the PD-MD group showed hypometabolism in lateral frontal, cingulate, and parieto-temporo-occipital cortices. CONCLUSIONS: The distribution of hypometabolic brain areas of the PD-MD group suggests that PD-MD seems to be caused by a common pathology with PD dementia. PD-SA and PD-SN seem to be caused by very mild or topographically heterogeneous cerebral dysfunction. Longitudinal clinical and neuroimaging studies are needed to define whether PD patients with single domain MCI progress to PD-MD and finally to dementia-
dc.description.statementOfResponsibilityopen-
dc.format.extent65~73-
dc.relation.isPartOfEUROPEAN NEUROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHBrain/diagnostic imaging*-
dc.subject.MESHBrain/metabolism-
dc.subject.MESHBrain Mapping-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHCerebral Cortex/diagnostic imaging*-
dc.subject.MESHCognition Disorders*/complications-
dc.subject.MESHCognition Disorders*/diagnostic imaging-
dc.subject.MESHCognition Disorders*/pathology-
dc.subject.MESHDementia/complications-
dc.subject.MESHDementia/diagnostic imaging-
dc.subject.MESHDementia/pathology-
dc.subject.MESHFemale-
dc.subject.MESHFluorodeoxyglucose F18-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMental Status Schedule-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeuropsychological Tests-
dc.subject.MESHParkinson Disease*/complications-
dc.subject.MESHParkinson Disease*/diagnostic imaging-
dc.subject.MESHParkinson Disease*/pathology-
dc.subject.MESHPositron-Emission Tomography-
dc.titleCerebral glucose metabolism of Parkinson's disease patients with mild cognitive impairment-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학)-
dc.contributor.googleauthorLyoo C.H.-
dc.contributor.googleauthorJeong Y.-
dc.contributor.googleauthorRyu Y.H.-
dc.contributor.googleauthorRinne J.O.-
dc.contributor.googleauthorLee M.S.-
dc.identifier.doi10.1159/000315036-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01333-
dc.contributor.localIdA02485-
dc.contributor.localIdA02753-
dc.relation.journalcodeJ00849-
dc.identifier.eissn1421-9913-
dc.identifier.pmid20606450-
dc.identifier.urlhttp://www.karger.com/Article/FullText/315036-
dc.subject.keywordParkinson’s disease-
dc.subject.keywordMild cognitive impairment-
dc.subject.keywordPositron emission tomography-
dc.contributor.alternativeNameLyoo, Chul Hyoung-
dc.contributor.alternativeNameRyu, Young Hoon-
dc.contributor.alternativeNameLee, Myung Sik-
dc.contributor.affiliatedAuthorLyoo, Chul Hyoung-
dc.contributor.affiliatedAuthorRyu, Young Hoon-
dc.contributor.affiliatedAuthorLee, Myung Sik-
dc.citation.volume64-
dc.citation.number2-
dc.citation.startPage65-
dc.citation.endPage73-
dc.identifier.bibliographicCitationEUROPEAN NEUROLOGY, Vol.64(2) : 65-73, 2010-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers

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