타이타늄 표면에 항생제를 함유한 생분해성 고분자 물질의 코팅에 따른 약물방출 및 항균효과

Abstract

Titanium and titanium alloys are the most common materials used for dental and biomedical implants, owing to their biocompatibility and favorable mechanical properties. However infection of the region surrounding a implant by pathogenic microorganisms is a significant factor in implant failure. Currently, a number of studies to create antibacterial surfaces of dental implants and biomaterials are being reported and commercially applied. Prevention and control of microbial colonization of implant surfaces is therefore of considerable interest to the biomedical community. One of the solutions, various biodegradable polymeric drug delivery devices have been developed for the sustained release of a variety of drugs. Among them, fi lms as implantable drug delivery systems have gained growing interest in various applications. The purpose of this study was to confirm the release of antibiotics and antibiotic effects of titanium surface which coated with biodegradable polymer and different concentrations of tetracycline. Anodized titanium specimen (diameter 8 mm, height 2 mm) were coated with poly (lactide) acid solution (1%) containing different concentrations of tetracycline (0.0%: Group I, 0.1%:Group II, 0.5%:Group III, 1.0%: Group IV). The coated specimen’s surface were observed by scanning electron microscope. For the analysis of drug release, the specimens were inserted in distilled water and then the solution was measured for 3 hours, 6 hours , 12 hours , 1 days, 3 days, 7 days, 14 days u sing the ultraviolet spectrometer. Antimicrobial activi ty against Staphylococcus aureous was tested wi th the agar di ffusion method. Scanning electron microscope image showed that polymer coating layers fulfi lled the ti tanium surface. The most of tetracycline released within 6 hours and then continued until 2 weeks. Regarding the antibacterial effect for Staphylococcus aureous, the specimens showed inhibitions of the strain with larger zones for the higher tetracycline concentration