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Soluble fms-like tyrosine kinase-1 and the progression of carotid intima-media thickness – 24-month follow-up study –.

 Sanghoon Shin  ;  Sang-Hak Lee  ;  Sungha Park  ;  Seok-Min Kang  ;  Namsik Chung  ;  Won-Heum Shim  ;  Seung-Yun Cho  ;  Ichiro Manabe  ;  Yangsoo Jang 
 CIRCULATION JOURNAL, Vol.74(10) : 2211-2215, 2010 
Journal Title
Issue Date
Aged ; Carotid Artery Diseases/pathology* ; Cholesterol, HDL/blood ; Disease Progression ; Follow-Up Studies ; Humans ; Hypertension ; Male ; Middle Aged ; Predictive Value of Tests* ; Tunica Intima/pathology* ; Vascular Endothelial Growth Factor A/blood ; Vascular Endothelial Growth Factor Receptor-1/blood*
Atherosclerosis ; Carotid arteries ; Hypertension ; Vascular endothelial growth factor ; Vascular endothelial growth factor receptor 1
BACKGROUND: The relationship between fms-like tyrosine kinase-1 (sFlt-1), a soluble receptor for vascular endothelial growth factor (VEGF), and vascular disease has not been established, so this study aimed to elucidate the association between sFlt-1 and the progression of carotid intima - media thickness (IMT) in hypertensive patients.

METHODS AND RESULTS: The 120 hypertensive patients under medical control were enrolled and 112 completed the study (age 59 ± 9 years, 57 females). Plasma VEGF and sFlt-1 levels were measured at enrollment. At baseline and 24-month visit, carotid IMT was measured and the association between sFlt-1 and IMT progression was assessed by linear regression. At baseline, age (r=0.186) and low level of high-density lipoprotein-cholesterol (HDL-C <40 mg/dl, r=0.214) were significantly related to carotid IMT. Over the 24 months, carotid IMT increased from 0.670 ± 0.089 mm to 0.696 ± 0.095 mm. There was a positive correlation between sFlt-1 tertiles and IMT change (P=0.05 by ANOVA). Upon multivariate analysis, log-transformed sFlt-1 level (β=0.137, P=0.003) and low HDL-C (β=0.048, P=0.04) were identified as predictors of IMT progression, independent of other confounding variables.

CONCLUSIONS: High sFlt-1 level is predictive of carotid IMT progression in hypertensive patients. Low HDL-C level was also associated with IMT change. These observations support a high sFlt-1 level being indicative of progression of atherosclerosis
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Seok Min(강석민) ORCID logo https://orcid.org/0000-0001-9856-9227
Park, Sung Ha(박성하) ORCID logo https://orcid.org/0000-0001-5362-478X
Shin, Sang Hoon(신상훈)
Shim, Won Heum(심원흠)
Lee, Sang Hak(이상학) ORCID logo https://orcid.org/0000-0002-4535-3745
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Chung, Nam Sik(정남식)
Cho, Seung Yun(조승연)
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