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Accuracy of 3 T MR angioraphy in vertebral artery stenosis and coincidence with other cerebrovascular stenoses

 Hyun Seok Choi  ;  Dong Ik Kim  ;  Dong Joon Kim  ;  Jinna Kim  ;  Eun Soo Kim  ;  Seung-Koo Lee 
 NEURORADIOLOGY, Vol.52(10) : 893-898, 2010 
Journal Title
Issue Date
Cerebrovascular Disorders/complications* ; Cerebrovascular Disorders/pathology* ; Female ; Humans ; Magnetic Resonance Angiography/methods* ; Male ; Middle Aged ; Reproducibility of Results ; Sensitivity and Specificity ; Vertebrobasilar Insufficiency/complications* ; Vertebrobasilar Insufficiency/pathology*
Atherosclerosis ; MR angiography ; Vertebral artery stenosis ; Intracranial stenosis
INTRODUCTION: Ostium of vertebral artery (VA) is a common site of pseudostenosis on contrast-enhanced MR angiography (CE-MRA). The purpose of this study was to determine the diagnostic accuracy of CE-MRA at 3 T in the evaluation of ostial stenosis of VA and to find associated coincidental stenoses using logistic regression analysis.

METHODS: One hundred and thirty-five VA ostial regions from 72 patients who received CE-MRA of neck vessels, intracranial time of flight (TOF) MRA, and digital subtraction angiography (DSA) were retrospectively reviewed. The sensitivity and specificity of the CE-MRA in detection of ostial stenosis were calculated with reference standard of DSA. Ostial stenosis on MRA was correlated with coincidental lesions in intracranial and cervical arteries by logistic regression analysis.

RESULTS: The sensitivity and specificity of the CE-MRA were 100% and 80.4% for detection of significant stenosis. In case of significant stenoses, CE-MRA showed a tendency of overestimation with a false-positive rate of 52.5%. Logistic regression analysis showed that the stenoses of middle cerebral artery (MCA) on TOF MRA was associated with significant stenoses of VA ostia (OR = 5.84, 95% confidence intervals 1.41-24.17).

CONCLUSION: CE-MRA is sensitive in detection of VA ostial stenosis although it has high false-positive rate. True positive ostial stenosis should be considered in cases of coincidental stenoses of MCA on TOF MRA.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Ik(김동익)
Kim, Dong Joon(김동준) ORCID logo https://orcid.org/0000-0002-7035-087X
Kim, Eun Soo(김은수)
Kim, Jinna(김진아) ORCID logo https://orcid.org/0000-0002-9978-4356
Lee, Seung Koo(이승구) ORCID logo https://orcid.org/0000-0001-5646-4072
Choi, Hyun Seok(최현석) ORCID logo https://orcid.org/0000-0003-4999-8513
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