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Enhanced chondrogenic responses of human articular chondrocytes onto silk fibroin/wool keratose scaffolds treated with microwave-induced argon plasma.

DC Field Value Language
dc.contributor.author박종철-
dc.contributor.author백현숙-
dc.contributor.author이영대-
dc.contributor.author이원재-
dc.date.accessioned2015-04-23T16:58:25Z-
dc.date.available2015-04-23T16:58:25Z-
dc.date.issued2010-
dc.identifier.issn0160-564X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/101583-
dc.description.abstractSilk fibroin (SF) is a natural, degradable, fibrous protein that is biocompatible, is easily processed, and possesses unique mechanical properties. Another natural material, wool keratose (WK), is a soluble derivative of wool keratin, containing amino acid sequences that induce cell adhesion. Here, we blended SF and WK to improve the poor electrospinability of WK and increase the adhesiveness of SF. We hypothesized that microwave-induced argon plasma treatment would improve chondrogenic cell growth and cartilage-specific extracellular matrix formation on a three-dimensional SF/WK scaffold. After argon plasma treatment, static water contact angle measurement revealed increased hydrophilicity of the SF/WK scaffold, and scanning electron microscopy showed that treated SF/WK scaffolds had deeper and more cylindrical pores than nontreated scaffolds. Attachment and proliferation of neonatal human knee articular chondrocytes on treated SF/WK scaffolds increased significantly, followed by increased glycosaminoglycan synthesis. Our results suggest that microwave-induced, plasma-treated SF/WK scaffolds have potential in cartilage tissue engineering.-
dc.description.statementOfResponsibilityopen-
dc.format.extent384~392-
dc.relation.isPartOfARTIFICIAL ORGANS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHArgon/chemistry-
dc.subject.MESHBombyx/chemistry-
dc.subject.MESHCartilage, Articular/cytology-
dc.subject.MESHCell Adhesion-
dc.subject.MESHCell Proliferation-
dc.subject.MESHCells, Cultured-
dc.subject.MESHChondrocytes/cytology*-
dc.subject.MESHChondrocytes/metabolism-
dc.subject.MESHFibroins/chemistry*-
dc.subject.MESHFibroins/isolation & purification-
dc.subject.MESHGlycosaminoglycans/metabolism-
dc.subject.MESHHumans-
dc.subject.MESHKeratins/chemistry*-
dc.subject.MESHMicrowaves-
dc.subject.MESHPorosity-
dc.subject.MESHSurface Properties-
dc.subject.MESHTissue Scaffolds*-
dc.subject.MESHWater/chemistry-
dc.subject.MESHWool/chemistry*-
dc.titleEnhanced chondrogenic responses of human articular chondrocytes onto silk fibroin/wool keratose scaffolds treated with microwave-induced argon plasma.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Medical Engineering (의학공학)-
dc.contributor.googleauthorYoung Woo Cheon-
dc.contributor.googleauthorWon Jai Lee-
dc.contributor.googleauthorHyun Sook Baek-
dc.contributor.googleauthorYoung Dae Lee-
dc.contributor.googleauthorJong-Chul Park-
dc.contributor.googleauthorYoung Hwan Park-
dc.contributor.googleauthorChang Seok Ki-
dc.contributor.googleauthorKie-Hyung Chung-
dc.contributor.googleauthorDong Kyun Rah-
dc.identifier.doi10.1111/j.1525-1594.2009.00871.x-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01662-
dc.contributor.localIdA01843-
dc.contributor.localIdA02954-
dc.contributor.localIdA03005-
dc.relation.journalcodeJ00246-
dc.identifier.eissn1525-1594-
dc.identifier.pmid20633153-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/j.1525-1594.2009.00871.x/abstract-
dc.subject.keywordCartilage tissue engineering-
dc.subject.keywordChondrocytes-
dc.subject.keywordMicrowave‐induced argon plasma-
dc.subject.keywordNanofibrous silk fibroin-
dc.subject.keywordScaffold-
dc.contributor.alternativeNamePark, Jong Chul-
dc.contributor.alternativeNameBaek, Hyun Sook-
dc.contributor.alternativeNameLee, Young Dae-
dc.contributor.alternativeNameLee, Won Jai-
dc.contributor.affiliatedAuthorPark, Jong Chul-
dc.contributor.affiliatedAuthorBaek, Hyun Sook-
dc.contributor.affiliatedAuthorLee, Young Dae-
dc.contributor.affiliatedAuthorLee, Won Jai-
dc.citation.volume34-
dc.citation.number5-
dc.citation.startPage384-
dc.citation.endPage392-
dc.identifier.bibliographicCitationARTIFICIAL ORGANS, Vol.34(5) : 384-392, 2010-
dc.identifier.rimsid40103-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Plastic and Reconstructive Surgery (성형외과학교실) > 1. Journal Papers

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