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Prevalence of Barrett's esophagus remains low in the Korean population: nationwide cross-sectional prospective multicenter study

Authors
 In Seok Lee  ;  Suck Chei Choi  ;  Ki Nam Shim  ;  Sam Ryong Jee  ;  Kyu Chan Huh  ;  Jun Haeng Lee  ;  Kwang Jae Lee  ;  Hyung Seok Park  ;  Yong Chan Lee  ;  Hoon Yong Jung  ;  Hyo Jin Park 
Citation
 DIGESTIVE DISEASES AND SCIENCES, Vol.55(7) : 1932-1939, 2010 
Journal Title
 DIGESTIVE DISEASES AND SCIENCES 
ISSN
 0163-2116 
Issue Date
2010
MeSH
Adult ; Age Distribution ; Analysis of Variance ; Barrett Esophagus/epidemiology* ; Barrett Esophagus/pathology* ; Barrett Esophagus/therapy ; Biopsy, Needle ; Confidence Intervals ; Cross-Sectional Studies ; Esophagitis, Peptic/diagnosis ; Esophagitis, Peptic/epidemiology ; Esophagitis, Peptic/therapy ; Esophagoscopy/methods ; Gastroesophageal Reflux/diagnosis ; Gastroesophageal Reflux/epidemiology ; Gastroesophageal Reflux/therapy ; Humans ; Immunohistochemistry ; Korea/epidemiology ; Male ; Middle Aged ; Multivariate Analysis ; Odds Ratio ; Prevalence ; Prospective Studies ; Severity of Illness Index ; Sex Distribution ; Young Adult
Abstract
PURPOSE: In contrast to the Western population, the prevalence of Barrett's esophagus (BE) is rare in the Korean population. However, the recent increase in prevalence of gastroesophageal reflux disease (GERD) may affect the prevalence of BE. The aim of this study was to survey the prevalence of BE and evaluate its risk factors. METHODS: Patients between 18 and 75 years of age who visited 11 Korean tertiary referral centers between April and July 2006 for routine upper endoscopic examination were surveyed using a symptom questionnaire. Biopsies were performed on the columnar lined epithelium (CLE) of the distal esophagus, and diagnosis was confirmed with detection of specialized intestinal metaplasia. RESULTS: The study comprised 2,048 patients (mean age 51.4 years, 965 males). The frequency of heartburn or acid regurgitation was 8.7% and 13.1%, respectively. Reflux esophagitis was diagnosed in 10.1% of patients (207 patients); however, most patients had mild reflux. CLE was found in 82 patients; however, only one patient had long-segment CLE. The prevalence of BE was 1% (21 patients). The risk factors for BE were age (P = 0.006), presence of heartburn [odds ratio (OR) 4.33, 95% confidence interval (CI) 1.66-11.34, P = 0.007], acid regurgitation (OR 3.37, 95% CI 1.35-8.42, P = 0.01), sliding hernia (OR 6.21, 95% CI 1.78-21.72, P = 0.001), and reflux esophagitis (OR 10.28, 95% CI 4.31-24.50, P < 0.0001) on univariate analysis. On multivariate analysis, presence of typical reflux symptoms (P = 0.02) and reflux esophagitis (P < 0.001) were significant. CONCLUSIONS: Prevalence of Barrett's esophagus remains low in Koreans; however, risk of developing BE has increased in patients with GERD symptoms and reflux esophagitis.
Full Text
http://link.springer.com/article/10.1007%2Fs10620-009-0984-0
DOI
10.1007/s10620-009-0984-0
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Hyo Jin(박효진) ORCID logo https://orcid.org/0000-0003-4814-8330
Lee, Yong Chan(이용찬) ORCID logo https://orcid.org/0000-0001-8800-6906
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/101257
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