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한국인 베체트 장염 환자에서 Thalidomide의 치료 경험:단일 기관의 초기 경험

Other Titles
 Clinical Experience of Thalidomide in the Treatment of Korean Patients with Intestinal Behçet’s Disease: Pilot Experience in a Single Center 
 이현정  ;  천재희  ;  이경주  ;  장희원  ;  정규식  ;  정은석  ;  이진하  ;  전승민  ;  홍성필  ;  김태일  ;  김원호 
 INTESTINAL RESEARCH, Vol.8(1) : 63-69, 2010 
Journal Title
Issue Date
Behçet Syndrome ; Gastrointestinal Disease ; Thalidomide
Intestinal Behçet’s disease (BD) often leads to severe complications, such as perforation or massive bleeding, and
therefore is one of the major causes of morbidity and mortality. As thalidomide has been identified and its
anti-inflammatory and immunomodulatory properties clarified, this drug has been used in cases of systemic BD with
some success. Herein we report a case series of four patients with intestinal BD to share our clinical experience
with thalidomide treatment. We studied the effects of thalidomide in four patients who had a chronic relapse of
intestinal BD requiring the frequent use of systemic steroids due to refractoriness to prior treatments, such as
5-aminosalycylic acid and immunosuppressants. Pre- and post-treatment clinical and laboratory data, including clinical
symptoms, laboratory data, disease activity index for intestinal BD, and thalidomide toxicity were recorded. Three
of the four patients had a clinical and radiologic improvement after thalidomide treatment and all of the patients
discontinued steroid therapy. Although two patients tolerated thalidomide, two patients could not continue the
treatment because they suffered from edema and neutropenia. Thalidomide could be considered a therapeutic option
for the treatment of intestinal BD.
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6. Others (기타) > Dept. of Health Promotion (건강의학과) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Won Ho(김원호) ORCID logo https://orcid.org/0000-0002-5682-9972
Kim, Tae Il(김태일) ORCID logo https://orcid.org/0000-0003-4807-890X
Lee, Kyong Joo(이경주)
Lee, Jin Ha(이진하)
Lee, Hyun Jung(이현정)
Jang, Hui Won(장희원)
Jeon, Soung Min(전승민)
Jung, Kyu Sik(정규식)
Jung, Eun Suk(정은석)
Cheon, Jae Hee(천재희) ORCID logo https://orcid.org/0000-0002-2282-8904
Hong, Sung Pil(홍성필)
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